Résumé
Les cytokines sont des facteurs solubles libérés suite à ľactivation des cellules immunitaires, en particulier les macrophages et les lymphocytes. Ces cytokines influencent les cellules immunocompétentes en contrôlant leur différentiation, activation et prolifération. Une hypothése pouvant éclairer la pathogenèse des maladies inflammatoires pourrait être la libération inadéquate de cytokines responsable d’un déficit du contrôle immunorégulateur.
Summary
Activation of immune cells, especially macrophages and lymphocytes, releases a series of soluble factors (cytokines) which act on neighbouring cells to control differentiation, activation and proliferation. One hypothesis for the pathogenesis of inflammatory bowel disease could be that abnormal release of cytokines might result in disordered immunoregulation.
Resumen
Las citokinas son factores solubles liberados como consecuencia de la activación de las células inmunitarias, en particular los macrófagos y los linfocitos. Estas citokinas actüan sobre las células inmunocompetentes controlando su diferenciación, activación y proliferación. Una hipótesis que podría aclarar la patogénesis de las enfermedades inflamatorias podría ser la liberación inadecuada de citokinas responsables de un déficit del control inmuno-regulador.
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Hoang, P., Jewell, D.P. Les cytokines dans la colite ulcéreuse et la maladie de Crohn. Acta Endosc 21, 233–238 (1991). https://doi.org/10.1007/BF02968711
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DOI: https://doi.org/10.1007/BF02968711