Summary
The effect of exercise on the dilute blood clot lysis time (B.L.T.), plasma fibrinogen, and serum anti plasmin has been investigated in two groups of healthy volunteers and in patients with multiple sclerosis.
The first group of normal volunteers were studied over a two hour period at rest and following exercise. The second group was investigated immediately before and five minutes after exercise. The patients with multiple sclerosis were similarly investigated.
The mean B.L.T. is longer in multiple sclerosis than in normal subjects. There is significant shortening of the B.L.T. and a rise, which does not reach significance, of the antiplasmins in both normal subjects and patients with multiple sclerosis, following exercise. The fibrinogen, which falls in normal subjects after exercise, rises in multiple sclerosis.
The importance of investigation of the fibrinolytic system over a period of time or following stimulation is stressed.
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Note—No. I of the present series was published in thisJournal in October, 1966, and No. II in February, 1967.
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O’Brien, E.T., Thornes, R.D., Waldron, M. et al. Physiology of fibrinolysis. I. J. Med. Sc. 1, 195–202 (1968). https://doi.org/10.1007/BF02958757
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DOI: https://doi.org/10.1007/BF02958757