Summary
Comparison of the iron binding capacity of gastric secretion under basal and histamine stimulated conditions showed no significant variation. However, following ‘flushing’ of the gastric mucosa the capacity to bind iron was approximately doubled. Since this procedure is known to cause increased mucus secretion it seems likely that the iron binding capacity in gastric juice is either of mucoid origin or associated with mucus secretion. From what is known of the properties of gastric iron binding the former seems to be the more likely. Furthermore since there is no evidence that iron binding in gastric juice is due to a single component it seems more appropriate to refer to ‘the iron binding capacity’ of gastric juice than to imply by the use of the name ‘Gastroferrin’ that a single entity is involved.
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Scott, J.M., Weir, D.G. The origin of iron chelating factors in gastric juice. I. J. Med. Sc. 2, 553–558 (1969). https://doi.org/10.1007/BF02955467
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DOI: https://doi.org/10.1007/BF02955467