Summary
THE purpose of the study was to investigate the effect of apple fibre on diabetic control and on plasma lipid levels in non insulin dependent maturity onset diabetes mellitus. Twelve patients (8 females and 4 males) ingested 15g of apple fibre per day over a period of 7 weeks. There was a significant improvement in diabetic control, as reflected by a fall in mean fasting plasma glucose (P<0.05) and in percentage glycosylated haemoglobin (p<0.005). There was a 5% decrease in plasma cholesterol and 4% increase in HDL-cholesterol with no change in plasma triglyceride. These results suggest that apple fibre may be a useful adjuvant in the management of non insulin dependent maturity onset diabetic patients.
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Burnstein, M., Samaille, J. 1960. Sur en dosage rapide du cholesterol lie aux α aux β lipoproteins du serum. Clin. Chim. Acta. 5, 609–610.
Calvert, G. D., Graham, J. J., Mannik, T., Wise, P. H., Yeates, R. A. 1978. Effects of therapy on plasma high density lipoprotein cholesterol concentration in diabetes mellitus. Lancet ii, 66–68.
Ditzel, J., Kjaergaard, J. J. 1978. Haemoglobin A1 c concentrations after initial insulin treatment for newly discovered diabetes. Br. Med. J. i, 741–742.
Durrington, P. N., Manning, A. P., Boulton, C. H, Hartog, M. 1976. Effect of pectin on serum lipids and lipoproteins, whole gut transit time and stool weight. Lancet ii, 394–396.
Gabbay, K. G., Hasty, K., Breslow, J. L., Ellison, R. C, Bunn, F. H., Gallop, I. M. 1977. Glycosylated haemoglobins and long term blood glucose control in diabetes mellitus. J. Clin. Endocrinol. Metab. 44, 859–864.
Gonen T., Rubenstein, A. H., Rochman, H., Tanaga, S. P., Horwitz, D. L. 1977. Haemoglobin A1: an indicator of the metabolic control of diabetic patients. Lancet i, 734–737.
Gordon, T., Castelli, W. P., Hjortland, M. C, Kannel, W., Dawber, T. R. 1977. High density lipoprotein as a protective factor against coronary heart disease. Am. J. Med. 62, 707–714.
Gormley, T. R., Kevany, J., Egan, J. P., McFarlane, R. 1977. Effect of apples on serum cholesterol levels in humans. Ir. J. Fd. Sci. Technol. 1, 117–128.
Jenkins, D. J. A., Leeds, A. R., Newton C., Cummings, J. A. 1975. Effect of pectin, guar gum and wheat fibre on serum cholesterol. Lancet i, 1116.
Jenkins, D. J. A., Wolever, T. M. S., Leeds, A. R., Gassull, M. A., Haisman, P., Dilawari, J., Goff, D. V., Metz, G. L., Alberti, G. M. M. 1978. Dietary fibres, fibre analogues and glucose tolerance: importance of viscosity. Br. Med. J. i, 1392–1394.
Jenkins, D. J. A., Wolever, T. M. S., Nineham, R., Taylor, R., Metz, G. L., Bacon, S., Hockaday, T. D. R. 1979. Guar crispbread in the diabetic diet. Br. Med. J. ii, 1744–1946.
Jenkins, D. J. A., Wolever, T. M. S., Taylor, R. H., Reynolds, D., Nineham, R., Hockaday, T. D. R. 1980. Diabetic glucose control lipids and trace elements on long-term guar. Br. Med. J. i, 1353–1354.
Keen, H., Rose, G. D. A., Boyns, D., Chlouverakis, A., Mistry, S. 1965. Blood sugar and arterial disease. Lancet ii, 505–508.
Kennedy, A. L, Lappin, T. R. J., Lavery, T. D., Hadden, D. R., Weaver, J. A., Montgomery, D. A. D. 1978. Relation of high density lipoprotein cholesterol concentration to type of diabetes and its control. Br. Med. J. ii, 1191–1194.
Kiehm, T. G., Anderson, J. W., Ward K., 1976. Beneficial effect of a high carbohydrate high fibre diet on hyperglycaemic diabetic man. Am. J. Clin. Nutr. 29, 895–899.
Lopes-Virella, M. F., Stone, P. G., Colwell, J. A. 1977. Serum high density lipoprotein in diabetic patients. Diabetologia 13, 285–291.
Michael B., Camejo, M., Jacobs, J., Parker, J., St. Cry, M., Ruderman, N. 1979. H.D.L. in diabetes Lancet i, 155.
Miller, N. E., Forde, H., Thelle, D. S., Mjos, D. 1977. High density lipoprotein and coronary heart disease: a prospective case control study. Lancet i, 965–968.
Nikkila, E. A. 1978. Metabolie regulation of plasma high density lipoprotein concentrations. Eur. J. Clin. Invest. 8, 111–113.
Roschlau, P., Bernt, E., Gruber, W. 1975. Enzymatic determination of total cholesterol in serum using peroxidase as indicating enzyme. Clin. Chem. 21, 941.
Siegel, S. 1956.Non parametric statistics for the behavioural sciences. McGraw Hill, pp. 75–83.
Simpson, R. W., Mann, J. I., Hockaday, T. D. R., Turner, R. C, Jelfs, R. 1979. Lipid abnormalities in untreated maturity onset diabetes and1 the effect of treatment. Diabetologia 16, 101–106.
Stanton K., 1978. HDL cholesterol in diabetes and heart disease. Lancet ii, 638.
Stein, S. M., Horn, D. B. 1972. The estimation of plasma glycerol using a reaction rate analyser. Clin. Chi m. Acta. 39, 293–300.
Trowell, H. 1975. Dietary fibre hypothesis of the aetiology of diabetes mellitus. Diabetes 24, 762–764.
Welch, S. G., Boucher, J. 1978. A rapid micro scale method for the measurement of haemoglobin A1(a+b+c). Diabetologia 14, 209–211.
Yudkin, J. S., Boucher, J., France, M. W., Swindlehurst, C. 1979. The relationship between concentrations of glycosylated haemoglobin and of serum high density lipoprotein cholesterol in diabetic patients. Clinical Science 56, 269–272.
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Based on P. D. Mayne’s Registrars Prize, Royal Academy of Medicine in Ireland, 1979.
We thank Miss O’Shaughnessy, dietitian, Federated Dublin Voluntary Hospitals, Comhlucht Siuicre Eireann Teo. for freeze drying the apples and Ceimici Teo for the alcohol used in the preparation of the dietary fibre.
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Mayne, P.D., McGill, A.R., Gormley, T.R. et al. The effect of apple fibre on diabetic control and plasma lipids. Ir J Med Sci 151, 36–41 (1982). https://doi.org/10.1007/BF02940140
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DOI: https://doi.org/10.1007/BF02940140