Abstract
A new major urinary protein alleleMup-lc with “null” activity was detected in males of the COP strain. The (BN X COP)F1 X COP backcross had significant segregation distortion of theMup-lc andAco-1 alleles that indicated a linkage between the genes, at a map distance of 13 ± 4 cM. The loci reside on the linkage group II of the rat with theb locus. According to our data and the results published previously, the map distance and the orientation of genes isb - 8 ± 4 -Mup-1 - 13 ±4-Aco-1. These genes form a syntenic group in both the mouse and the rat.
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Adams M, Baverstock P R, Watts C H S and Gutmann G A 1984 Enzyme markers in inbred ratRattus norwegicus strains. Genetics of new markers and strain profiles.Biochem. Genet. 22: 611–629
Bender K, Adams M, Baverstock P R, den Bieman M, Bissbort S, Brdicka R, Butcher G W, Cramer D V, von Deimling O, Festing M F W, Gunther E, Guttmann R D, Hedrich H J, Kendall P B, Kluge R, Moutier R, Simon B, Womack J E, Yamada J and van Zutphen B 1984 Biochemical markers in inbred strains of the rat (Rattus norvegicus).Immunogenetics 19: 257–266
Clark A J, Hickman J and Bishop J 1984 A 45 kilobase DNA domain with two divergently orientated genes is the unit of organization of the murine major urinary protein genes.EMBO J. 3: 2055–2064
Cook P J L, Robson E B, Buckton K E, Slaghter C A, Gray J E, Blank C E, James F E, Ridler M A C, Insley J and Hulten M 1978 Segregation of ABO AK1 and ACONS in families with abnormalities of chromosome 9.Ann. Hum. Genet. 41: 365–370
Douglas L T 1966 Meiosis. I. Association of non-homologous bivalents during spermatogenesis in white mice.Genetica 37: 466–480
Drapier J C and Hibbs J B 1985 Aconitase, a Krebs cycle enzyme with an iron-sulfur cluster is inhibited in tumor-cells cocultivated with activated macrophages.J. Leuk. Biol. 38: 66
Free A H and Free H M 1978Urinalysis in clinical laboratory practice 3rd printing (West Palm Beach, Fl.: CRC Press) p. 51
Froehlich H, Kugler P and Schiebler T H 1984 Sex differences of the protein pattern in the urine of castrated rats. Z.Mikrosk.-Anat. Forsch. 98: 86–106
Harris H and Hopkinson D A 1976Handbook of enzyme electrophoresis in human genetics (New York: Elsevier)
Husman B, Norstedt G, Mode A and Gustafsson J A 1985 The mode of growth hormone administration is of major importance for the excretion of the major male rat urinary proteins.Mol. Cell Endocrinol. 40: 205–210
Knopf J L, Gallagher J F and Held W A 1983 Differential multihormonal regulation of the mouse major urinary protein gene family in the liver.Mol. Cell Biol. 3: 2232–2240
Kondo Y and Yamada J 1983 Male urinary protein-1Mup-1 expression in the female rat.J. Hered. 74: 280–282
Lalley P A and McKusick V A 1985 Report of the committee on comparative mapping.Cytogenet. Cell Genet. 40: 536–566
Lowry O H, Rosebrough N J, Farr A L and Randall R J 1951 Protein measurement with the Folin phenol reagent.J. Biol. Chem. 193: 265–275
Nadeau J H and Eicher E M 1982 Conserved linkage of soluble aconitase and galactose-1-phosphate uridyl transferase in mouse and man. Assignment of these genes to mouse chromosome 4.Cytogenet. CellGenet. 34: 271–281
Nikaido H and Hayakawa J I 1984 A new allele at theMup-1 locus controlling an electrophoretic variant of major urinary proteins in mice.J. Hered. 75: 59–61
Nikaido H, Yamada J and Kondo Y 1982 Male urinary protein-1 (Mup-1) in the rat assigned to linkage group II.J. Hered. 73: 119–122
Schneider H and Kugler P 1984 Urinary protein pattern of rats after castration and treatment with sex hormones. Z.Mikrosk.-Anat. Forsch. 98: 873–892
Stolc V, Kunz H W and Gill T J III 1980 The linkage of glyoxalase-1 to the major histocompatibility complex in the rat.J. Immunol. 125: 1167–1170
van Zutphen L F M, Lagerwerf A, Bouw J and den Bieman M G C W 1981 Biochemical polymorphism in the rat genetics of three electrophoretic variants and characterization of inbred strains.Biochem. Genet. 19: 173–186
van Zutphen L F M, den Bieman M, Hedrich H J and Kluge R 1985 Assignment ofLap-1 to linkage group I of the rat (Rattus norvegicus).Biochem. Genet. 23: 599–606
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Stolc, V. Linkage ofaconitase-1 andmajor urinary protein-1 loci in male rats. J. Genet. 65, 145–151 (1986). https://doi.org/10.1007/BF02931147
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DOI: https://doi.org/10.1007/BF02931147