Summary
A TSH radioimmunoassay is described, which was used to investigate the behaviour of the TSH pituitary response (as measured by the secretory area) to TRH in groups of subjects of both sexes and different phases of gonadal activity. It is concluded that the TSH pituitary response is in no way affected by physiological variations in the plasma gonadal hormones. This independent behaviour of the TSH response, uninfluenced by gonadal activity, was apparently confirmed by the results in some pathological conditions (ovarian agenesis and primary male hypogonadism of various types) characterized by very low plasma levels of gonadal hormones.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Adams L., Maloof F.: The Effect of Estrogens on the Serum Level of Thyrotropic Hormone in Humans — J. clin. Invest.49, 1, 1970. (Abstract).
Carlson H. E., Jacobs L. S., Daughaday W. H. D.: Growth Hormone, Thyrotropin and Prolactin Responses to Thyrotropin Releasing Hormone Following Diethylstilbestrol Pretreatment — J. clin. Endocr.37, 488, 1973.
Faglia G., Beck-Peccoz P., Ferrari C.: Enhanced Plasma Thyrotropin Responses to Thyrotropin Releasing Hormone Following Estradiol Administration in Man — Clin. Endocr.2, 207, 1973.
Gual C., Kastin A. J., Scally A. V.: Clinical Experience with Hypothalamic Releasing Hormones. I. Thyrotropin Releasing Hormone — Recent Progr. Hormone Res.28, 173, 1972.
Haigler E. D., Pittman J. A., Jr.,Hershman J. M., Baugh Ch. M.: Direct Evaluation of Pituitary Thyrotropin Reserve Utilizing Synthetic Thyrotropin Releasing Hormone — J. clin. Endocr.33, 573, 1971.
Hall R., Amos J., Ormston B. J.: Radioimmunoassay of Human Serum Thyrotropin — Brit. med. J.1, 582, 1971.
Hall R., Ormston B. J., Besser G. M., Cryer R. J., McKendrick M.: The Thyrotropin Releasing Hormone Test in Diseases of the Pituitary and Hypothalamus — Lancet1, 759, 1972.
Hershman J. M., Pittman J. A., Jr.: Utility of Radioimmunoassay of Serum Thyrotropin in Man — Ann. intern. Med.74, 481, 1971.
Jensen S. E., Weeke J.: Israel J. med. Sci.8, 48, 1972. (Abstract).
Lemarchand-Béraud Th., Scazziga B. R., Genazzani A., Enderle B., Burkardt P., Vannotti A.: Réponse hypophysaire au TRH chez les sujets normaux. Utilité du test au TRH dans les affections thyroïdiennes — Schweiz. med. Wschr.103, 831, 1973.
Nicoloff J. T., Gross J. A., Appleman M. D.: In:Fellinger K., Hofer R. (Eds): Further Advances in Thyroid Research. Verlag der Wiener medizinischen Akademie, Wien, 1971; p. 1973.
Odell W. D., Vauslager L., Bates R.: Radioimmunoassay of Human Thyrotropin — In:Hayes R. L., Goswitz F. A., Murphy B. E. P. (Eds): Radioistopes in Medicine:in Vitro Studies. USAEC, Oak Ridge, Tenn. United States Atomic Energy Commission, 1968; p. 185.
Ormston B. J., Kilborn J. R., Garry R., Amos J., Hall R.: Further Observations on the Effect of Synthetic Thyrotropin Releasing Hormone in Man — Brit. med. J.2, 199, 1971.
Sanchez-Franco F., Garcia M. D., Cacicedo L., Martin-Zurro A., Escobar Del Rey F.: Influence of Sex Phases of the Menstrual Cycle on Thyrotropin (TSH) Response to Thyrotropin-Releasing Hormone (TRH) — J. clin. Endocr.37, 736, 1973.
Snyder P. J., Utiger R. D.: Response to Thyrotropin Releasing Hormone (TRH) in Normal Man — J. clin. Endocr.34, 380, 1972.
Snyder P. J., Utiger R. D.: Thyrotropin Response to Thyrotropin Releasing Hormone in Normal Females over Forty — J. clin. Endocr.34, 1096, 1972.
Valenti G., Coscelli C.: Sulle capacità delle proteine sieriche di fissare gli ormoni tiroidei nella senescenza normale e patologica — G. Geront.14, 4, 1966.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Valenti, G., Vescovi, P.P., Bernasconi, S. et al. Pituitary tsh response to TRH: Interrelationships with gonadal activity. La Ricerca in Clin. Lab. 6, 69–78 (1976). https://doi.org/10.1007/BF02901490
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02901490