Summary
Human heavy chain diseases offer an opportunity to examine the molecular events taking place in cells which produce naturally occurring structural variants of a well-studied complex protein. Extensive structural analyses have been carried out on many of these proteins and have revealed the existence of certain characteristic features. Current studies are beginning to elucidate the molecular biology underlying these structural features.
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Studies from the author’s laboratory were supported by funds from the National Cancer Institute, the Veterans Administration and INSERM.
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Buxbaum, J.N. Heavy chain diseases in man. La Ricerca in Clin. Lab. 6, 301–317 (1976). https://doi.org/10.1007/BF02899977
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DOI: https://doi.org/10.1007/BF02899977