Conclusions
-
1.
Serum lipid fractions as lipid phosphorus, phospholipids, cholesterol, cholesterol as oleate (esterined), neutral fats, and total lipids were defined and determined in normal male and female patients, twentytwo to seventy-two years of age. These serum lipid fractions must be determined to reflect the true blood lipid state.
-
2.
There is a marked variation from the arithmetic mean of the normal serum lipid fractions.
-
3.
Neither total cholesterol alone nor cholesterol and phospholipid determinations reflect high blood lipid changes.
-
4.
The ratio of phospholipid to cholesterol above 1.00 may be encountered in older individuals and below 1.00 in the young age group.
-
5.
One must determine the arithmetic mean values as a base line, because of the variations of the normal serum lipid fraction percentage, the difference in technique, and the variation in the terminology of certain blood lipid constituents.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Peters, John P. and van Slyke, Donald D.: Quantitative Clinical Chemistry. Interpretations. Vol. I. Williams and Wilkins Co., Balt.; 2nd ed.; p. 374, 1946.
Bloor, W. R.: Biochemistry of the Fatty Acids and their Compounds, the Lipids. Reinhold Publishing Co., New York; p. 1, 1943.
Harrow, Benjamin: A Textbook of Biochemistry. W. B. Saunders Co., Phil.; p. 110, 1950.
Thannhauser, Siegfried J.: Lipidoses. Diseases of the Cellular Lipid Metabolism. Oxford University Press, New York; 2nd ed.; p. 11, 1950.
Best, Charles H. and Taylor, Norman B.: The Physiological Basis of Medical Practice. Williams and Wilkins Co., Balt.; 5th ed.; p. 4, 1950.
Harrow, Benjamin: A Textbook of Biochemistry. W. B. Saunders Co.; Phil.; p. 122, 1950.
Hawk, Philip B.; Oser, Bernard L.; and Summerson, William H.: Practical Physiological Chemistry. Blakiston Co., Phila.; 12th ed.; p. 86–87, 1947.
Sinclair, R. G.: Role of Phospholipids of Intestinal Mucosa in Fat Absorption, with Additional Data on Phospholipids of Liver and Stomach and Skeletal Muscle. J. Biol. Chem.; 82:117–136, 1929.
Duncan, Garfield G.: Diseases of Metabolism. W. B. Saunders Co., Phil.; 2nd ed.; p. 162–167, 1947.
Blix, G.: Electrophoresis of Lipid-Free Blood Serum. J. Biol. Chem.; 137:495, 1941.
Fishberg, A. M.; Friedfeld, L.; Hoffman, I.; Stoller, E. R.; and Fishberg, E. H.: Beta-Hyperglobulinemia Produced by Cholesterol Feeding in the Rabbit. Proc. Soc. for Exper. Biol. and Med.; V. 75, 301–303, 1950.
Bloch, K.: The Intermediary Metabolism of Cholesterol. Circulation; 1:214, (Feb.) 1950.
Gubner, R. and Ungerleider, H. E.: Arteriosclerosis. A Statement of the Problem. Am. J. Med.; 6:60 (Jan.) 1949.
Turner, D.: Handbook of Diet Therapy. Univ. of Chicago Press, Chicago; p. 79, 80; 1946.
Gould, R. G.: The Comparative Metabolism of Dietary and Endogenous Cholesterol Differentiated by the use of Radioactive Carbon. Circulation; 2: 467, (Sept.) 1950.
Thannhauser, Siegfried J.: Lipidoses, Diseases of the Cellular Lipid Metabolism. Oxford University Press, New York, 2nd ed.; p. 37, 1950.
Sperry, W. M.: Cholesterol-esterase in Blood. Jour. Biol. Chem.; CXI, 467, 1935.
Klein, Willibald: Uber die enzymatische Hydrolyse der Cholesterinester. Zeitsch. f. Physiol. Chem.; CCLIX, 268, 1939.
Balfour, William M.: Human Plasma Phospholipid Formation: A Study made with the aid of Radiophosphorus. Gastroent.; 9: 686–694, 1947.
Gorman, J. W.: The Role of Lipids and Lipoproteins in Atherosclerosis. Science; 111: 166, 1950.
Gofman, J. W., Jones, H. B.; Lindgren, F. T.; Lyon, T. P.; Elliott, H. A.: and Strisower, B.: Blood Lipids and Human Atherosclerosis. Circulation; 2:161 (Aug.) 1950.
Leathes, J. B. and Raper, H. S.: The Fats. Monographs on Biochemistry. Longmans Green and Co., London: 2nd ed.; 1925.
Page, I. H.; Kirk, E.; Lewis, W. H., Jr.; Thompson, W. R. and van Slyke, D. D.: Plasma Lipids of Normal Men at Different Ages. J. Biol. Chem.; Ill, 613, 1935.
Schoenheimer. R. and Rittenberg, D.: Deuterium as an Indicator in the Study of Intermediary Metabolism. V. The Desaturation of Fatty Acids in the Organism. J. Biol. Chem.: 113:505, 1936.
Rittenberg, D. and Schoenheimer, D.: Deuterium as an Indicator in the Study of Intermediary Metabolism. VIII. Hydrogenation of Fatty Acids in the Animal Organism. J. Biol. Chem.; 117:485, 1937.
Mirsky, I. A.: The Source of the Blood Acetone Resulting from the administration of the Ketogenic Principles of the Anterior Hypophysis. Am. J. Physiol.; 115: 424, 1936.
Peters, John P. and van Slyke, Donald D.: Quantitative Clinical Chemistry. Interpretations. Williams and Wilkins Co., Balt,; V. I, 2nd ed.; p. 423, 1946.
Peters, John P. and van Slyke, Donald D.: Quantitative Clinical Chemistry. Interpretations. Williams and Wilkins Co., Balt,; V. I, 2nd ed.; p. 45, 1946.
Youngburg, G. E. and Youngburg, M. V.: Phosphorus Metabolism: System of Blood Phosphorus Analysis. J. Lab. and Clin. Med.; 16: 158–166, (Nov.) 1930.
Bloor, W. R.: A Method for, the Determination of Fat in Small Amounts of Blood. J. Biol. Chem.; 17:377, 1914.
Leiboff, S. L.: A Simplified Method for Cholesterol Determination in Blood. J. Biol. Chem.; 61, 177, 1924.
Maclagan, N. F.: Serum Colloidal Gold Reaction as Liver Function Test. Brit. J. Exper. Path.; 25: 15–20, 1944.
Hanger, F. M.: Serological Differentiation of Obstructive from Hepategenons Jaundice by Flocculation of Cephalin- Cholesterol Emulsions. J. Clin. Investigation; 18:261–269, (May) 1939.
Greenberg, D. M.: Colorimetric Determination of Serum Proteins. J. Biol. Chem.; 82:545, 1929.
Westergren, A.: Suspension stability in Pulmonary Tuberculosis. Acta med. Scandinav.; 54:247, 1921.
Kellner, A.; Correll, J. W. and Ladd, A. T.: Modification of Experimental atherosclerosis by means of Intravenous Detergents. Am. Heart J., 38:460, 1949.
Ahrens, E. H., Jr. and Kunkel, H. G.: Stabilization of Serum Lipid Emulsions by Serum Phospholipids; J. Exper. Med.; 90:409, 1949.
Morrison, Lester M.; Gonzalez, P. and Wolfson, E.: The Phospholipid Cholesterol Ratio as a Test for Atherosclerosis. Circulation; II:3 p. 472, (Sept.) 1950.
Alhrick, Margaret J., Man, Evelyn B. and Peters, John P.; Serum Lipids in Infections Hepatitis and Obstructive Jaundice. J. Clin. Invest.; 29:781, (June) 1950.
Jackson, Raymond S.; Wilkinson, Jr., Charles F.; Hand, Eugene A.; Waldron, A. M. and Vogel, William C.: The Relationship between the Phospholipids and the Cholesterol in Human Plasma. Circulation, II, 3:472, (Sept.) 1950.
Davis D., Stern, B. and Lesnick, G.: The Lipid and Cholesterol Content of the Blood of Patients with Angina Pectoris and Arteriosclerosis. Ann. Int. Med.; 11:354–360, 1937.
Steiner, Alfred: Cholesterol in Arteriosclerosis, with special reference to Coronary Arteriosclerosis. Med. Clinics of North America; 34:673, (May) 1950.
Gertler, M. M.: Garn, S. M. and Lerman, J.: The Interrelationships of Serum. Cholesterol, Cholesterol Esters and Phospholipids in Health and Coronary Artery Disease. Circulation; 2:205–214, 1950.
Watkin. Donald M.; Froeb, Herman F.; Hatch, Frederick T. and Gutman, Alexander B.: Effects of Diet in Essential Hypertension. II. Results with Unmodified Kempner Rice Diet in Fifty Hospitalized Patients. Am. J. Med.; IX, 4:442–493. (Oct.) 1950.
Kornerup, Valdemar: Concentrations of Cholesterol, Total Fat and Phospholipid in Serum of Normal Man. Arch. Int. Med.; 85:3, p. 398–415, (March) 1950.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Goldbloom, A.A. Clinical studies of blood lipid metabolism I. normal blood lipid variations of phospholipids, neutral fats, total lipids, and lipid fraction percentages. Amer. Jour. Dig. Dis. 19, 9–19 (1952). https://doi.org/10.1007/BF02893193
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02893193