Summary
HLA typing was performed for 17 antigens on cells from 189 unrelated, normal white Caucasians. No significant differences (p>0.05) in distributions of different markers were found among the age groups. There does not seem to be a relation between heterozygosity at HLA-A and HLA-Bloci and survival until old age.
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References
Bender K., Mayerová A., Klotzbucher B., Burckhardt K., Hiller Ch.: No Indication of Postnatal Selection at the HL-ALoci — Tissue Antigens7, 118, 1976.
Bender K., Rüter G., Mayerová A., Hiller Ch.: Studies on the Heterozygosity at the HLA GeneLoci in Children and Old People — In:Ragsmey R. H., Sorack J. V. (Eds): International Symposium on HL-A Reagents. Karger, Basel, 1973; p. 287.
Doherty P., Zinkernagel R.: Enhanced Immunological Surveillance in Mice Heterozygous at the H-2 Gene Complex — Nature (Lond.)256, 50, 1975.
Gerkins V. R., Ting A., Menck H. T., Casagrande J. T., Terasaki P. I., Pike M. C., Henderson B. E.: HL-A Heterozygosity as a Genetic Marker of Long-Term Survival — J. nat. Cancer Inst.52, 1909, 1974.
Gibofsky A., Jaffe E. A., Fotino M., Becker C. G.: The Identification of HL-A Antigens on Fresh and Cultured Human Endothelial Cells — J. Immunol.115, 730, 1975.
Macurova H., Ivanyi P., Sajdlova H., Trojan J.: HL-A Antigens in Aged Persons — Tissue Antigens6, 269, 1975.
Sasportes M., Dehay C., Fellous M.: Variations of the Expression of HL-A Antigens on Human Diploid Fibroblastsin Vitro — Nature (Lond.)233, 332, 1971.
Snell G., Dausset J., Nathenson S.: Histocompatibility — Academic Press, New York, 1976.
Terasaki P. I., McCleland J. D.: Microdroplet Assay of Human Serum Cytotoxins — Nature (Lond.)204, 998, 1964.
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Publication no. 113 from the Department of Basic and Clinical Immunology and Microbiology, Medical University of South Carolina, Charleston, S.C. 29401. Research supported in part by USPHS grant 09938.
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Pandey, J.P., Fudenberg, H.H. & Loadholt, C.B. HLA antigens in different age groups. La Ricerca Clin. Lab. 7, 220–223 (1977). https://doi.org/10.1007/BF02881817
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DOI: https://doi.org/10.1007/BF02881817