Conclusions
It can, therefore, be stated that in our 30 cases of peptic ulcer, the ion-exchange polymer Deacidite was found highly effective in 26 patients in eliminating all night pain within 48 hours of beginning of therapy, and in 27 patients in eliminating hunger pain. These effects were obtained without resorting to dietary restriction save for the elimination of seasoned food and alcohol, restrictions often not adhered to without untoward results. These symptomatic improvements were paralleled by the disappearance of circumscribed epigastric tenderness and muscle spasm, by radiographic evidence of healing, and by pronounced diminution of free and total gastric acidity.The polymer regimen did not prevent recurrent gastric hemorrhage in two cases, nor did it relieve a well marked gastric obstruction in one case, though in five cases the pre-therapy gastric retention noted radiographicallv disappeared under polymer therapy. No complications such as constipation or disturbances in acid or base balance occurred though the polymer was taken over a period of approximately one year.
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Greenblatt, I.J., Jacobi, M. & Cohen, T.D. Effect of a lysozyme inactivating anion exchange polymer in treatment of peptic ulcer: Experimental and clinical study. Amer. Jour. Dig. Dis. 18, 362–368 (1951). https://doi.org/10.1007/BF02876286
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DOI: https://doi.org/10.1007/BF02876286