Abstract
Fifty sevenKlebsiella strainsviz. K. pneumoniae (28),K. planticola (19),K. oxytoca (6),K. ornithinolytica (3) andK. terrigena (1) possessed lipolytic and rrealytic activity. The effect of imipenem and ofloxacin at subinhhibitory concentrations (sub-MICs) on these enzymic activities of 4 strains was studied. At all the concentrations tested (mainly at 1/4 of the MICs) imipenem enhanced lipase activity manifested by cleavage of the substrate Tween 20. The effect of ofloxacin was strain- and concentration-dependent but in most cases lipolytic activity was also increased. The antibiotics practically did not affect the urease activity of the strains.
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Hoštacká, A. Thein Vitro effect of imipenem and ofloxacin on enzymic activity ofKlebsiella strains. Folia Microbiol 45, 387–390 (2000). https://doi.org/10.1007/BF02817610
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DOI: https://doi.org/10.1007/BF02817610