Abstract
The analysis of information in nucleotide and amino acid sequence data from an investigator’s own laboratory, or from the ever-growing worldwide databases, is critically dependent on well planned and written software. Although the most powerful packages previously have been confined to workstations, there has been a dramatic increase over the last few years in the sophistication of the programs available for personal computers, as the speed and power of these have increased. A wide choice of software is available for the Macintosh, including the LaserGene suite of programs from DNAStar. This review assesses the strengths and weaknesses of LaserGene and concludes that it provides a useful and comprehensive range of sequence analysis tools.
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Olson, S. A. (1994) MacVector: an integrated sequence analysis package, inComputer Analysis of Sequence Data, Part II (Griffin, A. M. and Griffin, H. G., eds.), Humana, Totowa, NJ, pp. 195–201.
Mangalam, H. (1993) Striding the turf of the Gang of Four.Trends Biochem. Sci. 18, 187,188.
Douglas, S. E. (1994) DNA Strider, inComputer Analysis of Sequence Data, Part II (Griffin, A. M. and Griffin, H. G., eds.), Humana, Totowa, NJ, pp. 181–194.
Griffin, A. M. and Griffin, H. G. (eds.) (1994)Computer Analysis of Sequence Data, Part I, Humana, Totowa, NJ.
Markiewicz, P. (1991) Computer software for molecular biology.BioTechniques 10, 756–763.
Ahern, K. (1992) Macintosh sequence analysis software review: a comparison of functions.Gen. Eng. News 12, 6,7.
Hein, J. J. (1990) Unified approach to alignment and phylogenies.Meth. Enzymol. 183, 626–645.
Higgins, D. G. and Sharp, P. M. (1989) Fast and sensitive multiple sequence alignments on a microcomputer.Computer Appl. Biosci. 5, 151–153.
Salser, W., Bedilion, T., Fitz-Gibbon, S., Mohajer, P., and Hansen, S. (1993) DNA sequence assembly and editing products which permit direct visulaization of raw data traces from automated (fluorescent) sequencing data.J. NIH Res. 5, 81,82.
Cockerill, M. (1994) A versatile tool for retrieving molecular sequences: Entrez.Trends Biochem. Sci. 19, 94,95.
Sayle, R. and Bissell, A. (1992) RasMol: A program for fast realistic rendering of molecular structures with shadows, in10th Eurographics UK ’92 Conference. University of Edinburgh.
Linton, D., Clewley, J. P., Burnens, A. P., Owen, R. J., and Stanley, J. (1994) An intervening sequence (IVS) in the 16S rRNA gene of the eubacteriumHelicobacter canis.Nucleic Acids Res. 22, 1954–1958.
Gilbert, D. G. (1992)Mulfold, anonymous ftp to ftp.bio.indiana.edu.
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Clewley, J.P. Macintosh sequence analysis software. Mol Biotechnol 3, 221–224 (1995). https://doi.org/10.1007/BF02789332
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DOI: https://doi.org/10.1007/BF02789332