Summary
The action of Zirconium (Zr) on biological systems presents an enigma. It is ubiquitous, being present in nature in amounts higher than most trace elements. It is taken up by plants from soil and water and accumulated in certain tissues. The entry into animal systems in vivo is related to the mode of exposure and the concentration in the surrounding environment. Retention is initially in soft tissues and then slowly in the bone. The metal is able to cross the blood brain-barrier and is deposited in the brain and the placental barrier to enter milk. The daily human uptake has been known to be as high as 125 mg. The level of toxicity has been found to be moderately low, both in histological and cytological studies. The toxic effects induced by very high concentrations are nonspecific in nature. Despite the presence and retention in relatively high quantities in biological systems, Zr has not yet been associated with any specific metabolic function. Very little information is available about its interaction with the compounds of the genetical systems, such as nucleic acids. Apparently, the metal is neither an essential nor toxic element in the conventional sense. However, the increasing exposure to this element through its increasing use in new materials and following radioactive fallout, has increased the importance of the study of its effects on living organisms. The tetravalent nature of the ionic state and the high stability of the compounds formed are important factors that need to be considered, as also the accumulation of this element in the brain, reminiscent of the relationship between Al3+ and Alzheimer's disease.
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References
H. A. Schroeder and J. J. Balassa,J. Chron. Dis. 19, 573–586 (1966).
C. D. Hodgman (ed.),Handbook of chemistry and physics, 44th ed., Chemical Rubber Publishing Co., Cleveland, OH, (1962).
J. C. Bailer (ed.),The chemistry of co-ordination compounds, Reinhold, New York (1956).
J. V. Silverton and J. L. Heard,Inorg. Chem. 2, 243 (1963).
T. Osanai, K. Hayakawa, N. Kikuchi, S. Konno, K. Ito, N. Shibata, and S. Suzuki,Eisei Kagaku 35, 297–300 (1989).
F. A. Cotton and G. Wilkinson,Advanced inorganic chemistry: A comprehensive test, 2nd ed., First Wiley Eastern Reprint, New Delhi, (1969).
S. Syamal and M. R. Maurya,Indian J. Chem. Sect. A. Inorg. Phys. Theor. Anal. 24, 836–840 (1985).
B. Venugopal and T. D. Luckey (eds.),Metal toxicity in Mammals, Vol. 2, Plenum Press, New York, (1978).
P. B. Hammond and R. P. Beliles, in:Cassarett and Doull's Toxicology, The Basic Science of Poisons, 2nd ed., J. Doull, C. D. Klassen, and M. O. Audur eds., Macmillan & Co., London, 1980, pp. 409–467.
M. Sayer and K. Sreenivas,Science 247, 1056–1060 (1990).
P. D. Stecher (ed.), Merck Index, 7th ed., Merck and Co., Rahway, NJ, 1960.
W. B. Shelley and H. J. Hurley, Jr.,Acta Derm. Venereol. 55, 241–260 (1975).
S. A. McWilliams, I. Montogomery, D. M. Jenkinson, H. Y. Elder, S. M. Wilson, and A. M. Sutton,Br. J. Dermatol. 117, 617–626 (1987).
Lewis's Pharmacology, (Revised by J. Crossland, 4th ed.), E & S, London, 1970.
J. Severa,Radiobiologiya 17, 629–631 (1977).
J. Schubert,Science 105, 389 (1947).
J. Schubert,J. Lab. Clin. Med. 34, 313–317 (1949).
A. Grollman and E. F. Grollman,Pharmacology and Therapeutics, 7th ed., Lea and Febiger, Philadelphia, PA., 1970.
W. L. Epstein,Adv. Biol. Skin 11, 313–335 (1971).
G. L. Floersheim,Agents and Actions 21, 313–335 (1971).
J. C. Muhler, G. K. Stookey, and C. W. Beck,J. Dent. Res. 49, 529–531 (1970).
J. C. Muhler, G. E. Kelley, G. K. Stookey, F. I. Lindo, and N. O. Harris,J. Amer. Dent. Assn. 18, 142–145 (1970).
J. L. Turk and D. Parker,J. Invest. Dermatol. 68, 341–345 (1977).
B. H. Clarkson, J. S. Wefel, and I. Miller,J. Dent. Res. 63, 13–18 (1984).
V. R. Bobyleva,Stomatologiya 47, 19–22 (1986).
P. I. Chang,Biomaterials 2, 151–155 (1981).
J. S. Franco and J. Monterio,Folha. Med. 82, 47–51 (1981).
P. Christel, A. Meunier, M. Heller, J. P. Torre, and C. N. Peille,J. Biomed. Mater. Res. 23, 45–62 (1989).
J. Green,Bull. Geol. Soc. Am. 70, 1127 (1959).
B. Mason,Principles of Geochemistry, 2nd ed., Wiley, New York, 1958.
A. P. Vinogradov,The Geochemistry of rare and dispersed chemical elements in soil, 2nd ed., Consultant's Bureau Inc., New York, 1959.
J. Lounamaa,Ann. Bot. Soc. ‘Vanamo’ 29, 4 (1956).
D. N. Gomberg, P. O. Banks, and A. R. McBirney,Science (Washington) 162, 121–122 (1968).
M. C. Celorio, J. M. C. Villar, and F. G. Ojea,An Edafol. Agrobiol. 30, 697–719 (1971).
J. M. C. Villar and F. G. Ojea,An. Edafol Agrobiol. 31, 243–267 (1973).
C. W. Naeser G. A. Izett, and R. Wilcox,Geology (Boulder) 1, 93–95.
R. A. K. Tahirkheli and C. N. Naeser,J. Ariz. Agad. Sci. 10, 111–113 (1975).
E. Murad,J. Soil Sci. 29, 219–223 (1978).
D. A. Robson,Trans. Nat. Hist. Soc. Nort. Humbria. 52, 27–34 (1984).
A. J. Busacca and M. J. Singer,Geoderma 44, 43–75 (1989).
G. S. R. Krishnamurti, B. P. Sahi, and K. V. S. Satyanarayana,Indian J. Agric. Sci. 43, 946–953 (1973).
D. N. Chakravarty, J. Sehgal, and G. Dev,J. Indian Soc. Soil Sci. 27, 417–426 (1979).
Y. S. Kassem and A. A. Elwan,Egypt. J. Soil. Sci. 20, 57–64 (1980).
L. E. Domingo and K. Kyuna,Plant Nutr. 29, 439–452 (1983).
R. F. Palumbo and F. G. Lowman,U.S. Atomic Energy Comm. Doc., UWFL-56, (1958).
H. L. Mills and L. M. Shields,Radiation. Bot. 1, 84–91 (1961).
E. M. Romney, A. J. Steen, R. A. Wood, and W. A. Rhoads, in:Radiological Concentration Processes: Proceedings of an International Symposium in Stockholm, B. Aberg and F. P. Hungate, eds., Pregman Press, London, 1966, pp. 391–397.
R. Nakamura, Y. Suzuki, and T. Ueda,J. Radiat. Res. 18, 322–330 (1977).
M. Albertsten and G. Matthess,Meyniana 32, 7–72 (1980).
S. Mattsson and R. Vesanen,Environ. Int. 14, 177–180 (1988).
R. G. Cuddihy, G. L. Finch, G. L. Newton, F. F. Hahn, J. A. Mewhinney, S. J. Rothenberg, and D. A. Powers,Environ. Sci. Technol. 23, 89–95 (1989).
P. Kresten and J. Chysster,J. Geol. Foren. Stockh. Forh. 111, 181–185 (1989).
M. D. Kleinkoff,Bull. Geol. Soc. Am. 71, 1231 (1960).
W. H. Duram and J. Haffty,Cine. U.S. Geol. Surv. (Washington) 445 (1961).
J. F. Slowey, D. Hedges, and D. W. Hood,The chemistry and analysis of trace metals in sea water, Texas A & M Research Foundation Report on USAEC 62-91A, 1962.
J. F. Slowey, D. Hayes, B. Dixon, and D. W. Hood, in:Marine Geochemistry, D. R. Schink and T. R. Corliss, eds., Occasional Publ., 3, 1965, pp. 109–129.
A. Yamato, N. Miyagawa, and N. Miyanaga,Radioisotopes 33, 449–455 (1984).
E. Oudin and A. Cocherie,Geochim. Cosmochin. Acta 52, 177–184 (1988).
V. M. Shevtsova,Gig. Tr. Prof. Zabol. 12, 24–30 (1968).
M. F. Lemyasev, L. G. Babushkina, G. V. Semenov, B. A. Katsnel'son, I. V. Karagodina, S. I. Treiger, and G. V. Belobragina,Gig. Sanit. 35, 38–41 (1970).
P. Misaelides, C. Sikalidis, R. Tsitourilou, and C. Alexiades,Distribution of Fission products in dust samples from the region of Thessaloniki, Greece after the chernobyl Nuclear accident. Arch. Environ. Health, Bull. Environ. Contam. Toxicol., Oil and Chemical Pollution, (1987).
T. J. Beveridge and S. F. Koval,Appl. Environ. Microbiol. 42, 325–335 (1981).
A. Collier,Science 118, 329 (1953).
F. G. Lowman, R. A. Stevenson, R. M. Escalera, and S. L. Ufret,Radiological Concentration Processes: Proceedings of an International Symposium in Stockholm, B. Aberg and F. P. Hungate, eds., Pregman Press, Oxford, London, 1966, pp. 735–751.
E. E. Held, inRadioecology, V. Schultz and A. W. Klement, Jr., eds., Reinhold, New York, 1963, pp. 577–579.
R. Nakamura, Y. Suzuki, and T. Ueda,J. Radiat. Res. 16, 224–236 (1975).
H. Mann and W. S. Fyfe,Biorecovery 1, 3–26 (1989).
F. G. Lowman, R. F. Palumbo, and D. J. South,U. S. Atomic Energy Comm. Doc., UWFL-51, (1957).
R. F. Palumbo,USAEC Report, UWFL-61, 1959, p. 32.
P. Eckl, R. Turk, and W. Hofmann,Noro. J. Bot. 4, 521–524 (1984).
P. Eckl, W. Hofmann, and R. R. Turk,Radiat. Environ. Biophys. 25, 43–54 (1986).
W. C. Hanson, H. E. Palmer, and B. I. Griffin,Health Physics 10, 421–429 (1964).
W. C. Hanson, D. G. Watson, and R. W. Perkins, in:Radiological concentration processes, B. Aberg and F. P. Hungate, eds., Pregman Press, Oxford, London, 1966, pp. 233–245.
T. A. Paribok, N. A. Sazykina, V. N. Toporskii, and T. I. Nikolaeva,Bot. Zh. Leningr. 72, 981–986 (1987).
S. Wojcik, A. Krupinski, W. Krasucki, L. Saba, and B. Rzaczynski.Pol. Arch. Water 16, 379–391 (1973).
M. A. Naryshkin, R. M. Alkshakhin, A. A. Molchanov, A. D. Vakurov, and N. N. Mishenkov,Lesovedenie 4, 104–107 (1975).
V. M. Klechkovsky and I. V. Guliakin, Behaviour of tracer amounts of strontium, caesium, ruthenium and zirconium in soils and plants according to the date of investigations with radiosotopes of these elements. USSR Ministry of Agriculture, Moscow, USSE, (1950).
J. Wlamis and G. A. Pearson,Science 111, 112 (1950).
E. M. Romney, H. Nishita, J. H. Olafson, and K. H. Larson,Soil Sci. Soc. Amer. Proc. 27, 383–385 (1963).
H. Nishita, E. M. Romney, and K. H. Larson, in:Radioactive Fallout, Soils, Plants, Foods, Man, E. B. Fowler, ed., Elsevier, New York, 1965.
N. I. Sanzharova and R. M. Aleksakhin,Pochvovedenie 0, 59–65 (1982).
D. Charles and D. Prime,Environ. Pollut. Ser. B. Chem. Phys. 5, 273–296 (1983).
L. Ferrara, P. Forgione, O. Schettino, and V. Rullo,Boll. Soc. Ital. Biol. Sper. 61, 1343–1348 (1985).
J. W. Budzynski and W. H. Fuller,Appl. Agric. Res. 1, 175–181.
H. A. Schroeder, W. H. Vinton, and J. J. Balassa,J. Nutr. 80, 39–47 (1963).
H. A. Schroeder, M. Mitchener, J. J. Balassa, M. Kanisawa, and A. P. Nason,J. Nutr. 95, 95–101 (1968).
B. Kawin, D. H. Copp, and J. G. Hamilton,Univerity of California Radiation Lab. Report, UCRL812, 1950, pp. 1–9.
J. Mealey,Nature 179, 673–674 (1957).
N. Ishinishi and T. Morishige.J. Radiat. Res. 10, 101–106 (1969).
J. G. Hamilton,New Engl. J. Med. 240, 863–865.
K. W. Cochran, J. Doull, M. Mazur, and K. P. DuBois,Arch. Industr. Hyg. 1, 637–650 (1950).
J. Blackstrom, L. Hammerstrom, and A. Nelson,Acta Radiobiologica Ther. Phys. Biol. 6, 122–128 (1967).
Y. Shiraishi and R. Ichikawa,Health Phys. 22, 373–378 (1972).
N. O. Razumovskij, L. M. Baranovskaya, and O. L. Torchinskaya,Gig. Sanit. 3, 53–58 (1974).
B. Patel, S. Patel and M. C. Balani,Proc. R. Soc. Lond. B. Biol. Sci. 224, 23–42 (1985).
L. H. Hyman,The Invertebrates: Protozoa through Ctenophora, McGraw-Hill London, 1940, p. 726.
D. Howes and J. G. Black,Toxicology 5, 209–220 (1975).
H. A. Schroeder and A. P. Nason,Clin. Chem. 17, 461–474 (1971).
A. Ando I. Ando, M. Takeshita, T. Hiraki, and K. Hisada,Eur. J. Nucl. Med. 6, 221–226 (1981).
A. Ando and I. Ando,Nucl. Med. Biol. 13, 21–30 (1986).
A. Ando, I. Ando, T. Hiraki, and K. Hisada,Nucl. Med. Biol. 16, 57–80 (1989).
T. Morishige,Jpn. J. Hyg. 23, 400–405 (1968).
H. A. Schroeder, M. Mitchener, and A. P. Nason,J. Nutr. 100, 59–68.
J. L. Delongeas, D. Burnel, P. Netler, M. Gignon, J. M. Mur, J. J. Royer, and G. Gignon,Lab. Pharmacol. 14, 437–447 (1983).
S. J. Waligora,Health Phys. 20, 89–91 (1971).
R. G. Thomas, S. A. Walker, and R. O. Mochellan,Proc. Soc. Exp. Biol. Med. 138, 228–234 (1971).
L. G. Barsegvan, O. V. Klykov, and D. P. Osanov,Gig. Sanit. 10, 32–34 (1981).
E. L. Dobson, J. W. Gofman, H. B. Jones, L. S. Kelly, and L. A. Walker,J. Lab. Clin. Med. 343, 305–312 (1949).
H. A. Schroeder,J. Chron. Dis. 18, 217 (1965).
A. Ando, I. Ando, M. Katayama, S. Sanada, T. Hiraki, H. Mori, N. Tonami, and K. Hisada,Eur. J. Nucl. Med. 12, 567–572 (1987).
A. Ando, I. Ando, M. Katayama, S. Sanada, T. Hiraki, H. Mori, N. Tonami, and K. Hisada,Eur. J. Nucl. Med. 14, 352–357 (1988).
M. E. J. Curzon, F. L. Losee, and A. D. McAlister,NZ. Dent. J. 71, 80–83 (1975).
L. S. Chuang and J. F. Emery,J. Radianal. Chem. 45, 169–180 (1978).
L. Q. Lin and H. F. Wen,Chin. J. Prev. Med. 22, 98–100 (1988).
A. Ando, I. Ando, S. Sanada, T. Hiraki, and K. Hisada,Eur. J. Nucl. Med. 10, 262 (1985).
H. A. Schroeder and A. P. Nason,J. Nutr. 106, 198–203.
V. I. Levin, L. P. Starovoitnova, G. E. Kodina, N. F. Tarasov, and M. D. Kozlova,Med. Radiol. 21, 38–43 (1976).
U. Iske, M. Bullmann, and F. Glomitza,Acta Biotechnol 7, 401–407 (1987).
W. B. Blumenthal,Am. Ind. Hyg. Assoc. J. 34, 128–133 (1973).
S. P. Tandon and A. S. Srivastava,Sydowia Ann. Mycol. 25, 137–142 (1971).
S. A. Peterson, W. O. Sanville, F. S. Stay, and C. F. Powers,J. Water Pollut. Control Fed. 48, 817–831 (1976).
W. D. Sanville, C. F. Powers, G. S. Schuytema, F. S. Stay, and W. L. Laver,J. Water Pollut. Control Fed. 54, 434–443.
D. A. Krivolutskii and T. I. Kozhevnikova,Ekologiya 3, 69–74.
J. E. Mckee and H. W. Wolf (eds.),Water Quality Criteria, 2nd end., State Water Pollution Control Board, Publication No. 3-A, Sacramento, CA., 1963.
D. T. McClinton and J. Schubert,J. Pharmacol. 94, 1–5 (1948).
D. M. Spink,Ind. Engr. Chem. 53, 97–104 (1961).
E. Browning,Toxicity of Industrial Metals, 2nd ed., Butterworths, London, 1969.
E. Browning,Toxicity of Industrial Metals, Butterworths, London, 1961, p. 323.
J. T. Prior, G. P. Cronk, and D. B. Ziegler,Arch. Environ. Health 1960, 297–301 (1960).
P. J. Dierick,Toxicol. Lett.,6, 235–238 (1980).
W. B. Shelley,Cancer Research 33, 287–292 (1973).
W. B. Shelley and C. J. Raque,J. Invest. Dermatol. 57, 411–417 (1971).
J. K. Draenert, A. Gruenert, and G. Ritter,Aktueltraumatol 7, 35–48 (1977).
H. A. Schroeder,J. Nutr. 94, 475, (1968).
C. R. Fletcher,Health Phys. 16, 209–220 (1969).
P. O. Ganrot,Environmental Health Perspectives 65, 363–441 (1986).
A. Pizzoferrato, A. Vespucci, G. Ciapetti, S. Stea, and C. Tarabusi,J. Biomed. Mater. Res. 21, 419–428 (1987).
J. R. Brown, E. Mastromatteo, and J. Horwood,Am. Ind. Hyg. Assoc J. 24, 131–136 (1963).
A. V. Roshchin, L. A. Taranenko, and N. Z. Muratova,Gig. Tr. Prof. Zabol. 2, 5–8 (1982).
J. L. Turk, in:Mechanisms of Toxicity, W. N. Aldridge, ed., Macmillan & Co., London, 1971, pp. 103–110.
K. Y. Kang, D. Bice, E. Hoffman, R. D'Amato, and J. Salvaggio,J. Allergy Clin. Immunol. 59, 425–436 (1977).
J. L. Turk and R. B. Narayanan,Immunobiology 161, 274–282 (1982).
S. Y. Li Hsu, M. E. Hsu, G. L. Lust, and J. R. Davis,J. Reticuloendothel. Soc. 12, 418–435 (1972).
J. R. Leininger, R. L. Farell, and G. R. Johnson,Arch. Pathol. Lab. Med. 101, 545–549 (1977).
J. L. Turk and D. Parker,J. Invest. Dermatol. 68, 336–340 (1977).
K. Y. Kang and J. Salvaggio,Tohoku J. Exp. Med. 126, 317–324 (1978)
C. G. Uragoda and M. R. M. Pinto,Med. J. Aust. 59, 167–169 (1977).
P. P. Lyarskii, L. T. Elovskaya, and T. Yu. Kapitanov,Khig. Zdraveopaz 20, 65–69 (1977).
N. N. Bukharovich, N. M. Speranskii, I. Ya. Zakharov, and A. F. Malitskii,Gig. Tr. Prof. Zabol. 16, 35–37 (1972).
M. Hadji, C. Olympia, and R. Brubaker,J. Occup. Med. 28 543–547 (1981).
L. Rubin, A. H. Slepyan, L. F. Weber, and I. Neuhauser,J. Am. Med. Assoc. 162, 953–955 (1956).
W. B. Shelley and H. J. Hurley,Brit. J. Dermatol. 70, 75–101.
W. L. Epstein,J. Invest. Dermatol. 34, 183–188 (1960).
W. L. Epstein, J. R. Skahen, and H. Krasnobrod,J. Invest. Dermatol. 38, 223–232 (1962).
W. B. Shelley, J. J. Hurley, R. L. Maycock, H. P. Close, and H. C. Catheart,J. Invest. Dermatol. 31, 301–303 (1958).
W. Jones-Williams,Verh. Dtsch., Ges. Pathol. 64, 177–180 (1980).
M. J. M. Pineiro, K. Fukuyama, W. L. Epstein, and G. Rowden,J. Clin. Pathol. 81, 563–568 (1984).
W. L. Epstein and H. Krasnobrod,Lab. Invest. 18, 190–195 (1958).
V. N. Shevaga,Vrach. Delo. 0, 95–99 (1981).
N. Ham-Kathryn, D. J. Brown, J. K. Dawborn, C. I. Johnson, S. Nelson, and J. M. Xipell,Pathology 17, 458–463 (1985).
A. Levan,Nature 156, 751–752 (1950).
E. C. Anderson, L. M. Holland, J. R. Prine, and D. M. Smith,Radiat. Res. 78, 82–97 (1979).
A. N. Stroud,Radiat. Res. 69, 583–590 (1977).
R. J. Price and N. SkilleterToxicol. Lett. 30, 86–96 (1986).
S. Sima, H. Kurita, T. Kuramoto, H. Hosoda, Y. Ukai, T. Yoshida, S. Tachikawa, Y. Ito, and K. Morita,Jpn. J. Hyg. 43, 895–900 (1988).
S. Ghosh,Ph.D. diss., University of Calcutta, India, 1990.
S. Ghosh, A. Sharma, and G. Talukder,Mutat. Res. 243, 29–30 (1990).
T. Jeffrey and T. J. Marks,J. Am. Chem. Soc. 107, 947–953 (1985).
P. Koeof-Maier, B. Hesse, and H. Koepf,J. Cancer Res. Clin Oncol. 96, 43–52 (1980).
B. S. Gould,Proc. Soc. Exptl. Biol. Med. 34, 381–385 (1936).
C. T. Huber and E. Frieden,J. Biol. Chem. 245, 3979–3984 (1970).
J. F. Kenedy, A. S. Barker, and J. D. Humphreys,J. Chem. Soc. Perkin. Trans. I. 9, 962–967 (1976).
M. K. Singh and M. N. Srivastava,Talanta 19, 699–700 (1972).
R. C. Tewari and M. N. Srivastava,Talanta 20, 360–361 (1973).
G. A. Ivarsson, P. O. Hegg, K. I. Lundstrom, and U. L. F. Jonsson,Colloids Surf. 13, 169–192 (1985).
M. H. Davis and J. G. Scroggie,Aust. J. Chem. 27, 279–286 (1974).
A. H. Wardi and G. A. Michos,Anal Biochem. 51, 274–279 (1973).
L. K. Harding and D. H. Keeling,Int. J. Appl. Radiat. Isot. 23, 253 (1972).
M. F. Liisberg,Acta Anat. 69, 655–666 (1968).
T. Kijima and S. Ueno,Chem. Soc. Daton Trans. 6, 61–66 (1986).
M. H. Davis and J. G. Scroggie,Int. J. Peptide Protein Res. 4, 319–325 (1972)
M. H. Abdelwahed, and M. Ayad,Anal. Lett. 17, 205–216 (1984).
T. Ito, S. Shima, K. Morita, S. Tachikawa, H. Kurita, T. Yoshida, K. Nagaoka, H. Hosoda, and K. Nagai,Jpn. J. Hyg. 41, 951–956 (1987).
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Ghosh, S., Sharma, A. & Talukder, G. Zirconium. Biol Trace Elem Res 35, 247–271 (1992). https://doi.org/10.1007/BF02783770
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DOI: https://doi.org/10.1007/BF02783770