Summary
Since the thymus is thought to play an important role in the pathogenesis of ulcerative colitis, thymic abnormalities were studied on 18 cases of ulcerative colitis by using pneumomediastinography and histopathological examination. We have compared the thymic abnormality of ulcerative colitis with that of 104 cases of variety of autoimmune diseases.
The denser and larger thymic shadow was seen in ulcerative colitis and this finding was same as in other autoimmune diseases. But the thymic size in ulcerative colitis was the largest in all examined autoimmune diseases.
The incidence of thymic lymphoid follicle formations in ulcerative colitis was significantly higher than that of accidental death and this high incidence of lymphoid follicle formation is similar to other autoimmune diseases. We suggested that ulcerative colitis might be caused by the abnormal thymus dependent system.
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References
Condorelli, L.: II Pneumo-mediastino artificiale. Minerva Med., 27: 81, 1936.
Tsuchiya, M.: Pneumomediastinography. Nichi-Futsu Igaku, 5: 91–97, 1958 (in Japanese)
Tsuchiya, M.: Thymus—its special biopsy. Medicina, 11: 1041–1043, 1974 (in Japanese).
Yoshimatsu, H. et al.: Mediastinoscopy and its application; thymectomy via the suprasternal notch. Keio J. Med., 20: 29–43, 1971.
Boyd, E.: The weight of the thymus gland in health and disease. Amer. J. Dis. Child., 43: 1162–1214, 1932.
Simecek, C.: Diagnostic pneumomediastinography. Dis. Chest, 53: 24–29, 1968.
Benendo-Kapusciriska, B. and Malanowska, S.: Diagnostic pneumomediastinography in 100 cases of myasthenia gravis. Polish Medical J., ii: 1292–1298, 1972.
Hare, W.S.C. and Mackay, I.R.: Radiological assessment of thymic size in myasthenia gravis and systemic lupus erythematosus. Lancet, i: 746–748, 1963.
Irvine, W.J. and Sumerling, M.D.: Radiological assessment of the thymus in thyroid and other diseases. Lancet, i: 998–999, 1965.
Michie, W. et al.: Quantitative radiological and histological studies of the thymus in thyroid diseases. Lancet, i: 691–695, 1967.
Hare, W.S.C. and Mackay, I.R.: Thymic size in systemic lupus erythematosus. Arch. Intern. Med., 124: 60–63, 1969.
Nakata, Y. et al.: Pneumomediastinography in autoimmune diseases. Jap. J. Clin. Immunol., 5: 865–869, 1973 (in Japanese).
Nakata, Y. et al.: Pneumomediastinography in patients with hypoplastic anemia. Jap. J. Clin. Hematology, 14: 757–761, 1973 (Japanese with English abstracts).
Tsuchiya, M. et al.: Thymic hyperplasia and therapeutic approach of thymectomy in Behcet’s syndrome. Biochemistry and Experimental Biology, 11: 47–52, 1974.
Schmid, K.O.: Thymus and ulcerative colitis. Verhand. Deutsch. Gesell. Pathol., 54: 313–319, 1970.
Nokita, H. et al.: Thymectomy on ulcerative colitis. Jap. J. Gastroentero. Surg., 6: 169–170, 1973 (in Japanese).
Kreel, L. et al.: Pneumomediastinography by the trans-sternal method. Clin. Radiol., 15: 219–223 1964.
Latos, D.L. and Burns, W.M.: Diagnostic pneumomediastinography. South. Med. J., 66: 1073–1074, 1973.
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Mizuno, Y., Shimabukuro, K., Kurita, K. et al. Thymus abnormalities in ulcerative colitis —comparative study with other autoimmune diseases. Gastroenterol Jpn 11, 208–214 (1976). https://doi.org/10.1007/BF02777706
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DOI: https://doi.org/10.1007/BF02777706