Summary
To determine the effects of methionine-enkephalin on secretion of pancreatic hormones, five healthy male adults were intramuscularly given 0.5 mg of FK 33-824, a methionine-enkephalin analog and blood levels of pancreatic hormones were measured at different time intervals.
FK 33-824 significantly lowered basal levels of plasma insulin (IRI) and pancreatic polypeptide and decreased IRI secretion in 75 g-OGTT. It also delayed the elevation of blood sugar level in 75g-OGTT. No change occurred in the basal levels of plasma glucagon, somatostatin and blood sugar. These results imply that methionine-enkephalin in the pancreas and alimentary tract may act as an inhibitor on the secretion of insulin and pancreatic polypeptide and hence relates to the absorption of sugar.
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Sekiya, K., Funakoshi, A., Shinozaki, H. et al. Influence of methionine-enkephalin analogue (FK-33-824) on the secretion of pancreatic hormones. Gastroenterol Jpn 20, 252–259 (1985). https://doi.org/10.1007/BF02774712
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DOI: https://doi.org/10.1007/BF02774712