Summary
Although several investigators have reported serum α-fetoprotein positive gastric cancer with or without metastasis to the liver, its site of production is still unclear. We studied on the site of α-fetoprotein synthesis in our cases which showed remarkably high level of serum α-fetoprotein, and clarified the presence of αfetoprotein producing gastric cancer by means of direct immunofluorescent technique. However, we also knew the hepatocytes adjacent to the metastatic lesions could also synthesize α-fetoprotein, although these hepatocytes were not known whether under regeneration or degeneration. Through this study, the other carcinofetal proteins such as carcino-placental alkaline phosphatase and CEA were examined using the sera or tumor tissues. Our results will support the idea that cancer is the disease of cell differentiation.
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Okita, K., Noda, Ki., Kodama, T. et al. Carcino-fetal proteins and gastric cancer. Gastroenterol Jpn 12, 400–406 (1977). https://doi.org/10.1007/BF02774538
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DOI: https://doi.org/10.1007/BF02774538