Abstract
We report a case of columnar cell carcinoma of the thyroid. A 47-year-old Japanese man had a nonencapsulated thyroid mass that infiltrated the surrounding tissues extensively. Seventeen months after thyroidectomy he died of respiratory failure resulting from tracheal invasion. An autopsy showed distant metastases to the liver, lung, esophagus, and pancreas. Histologically, the thyroid mass consisted of tall columnar atypical cells with marked nuclear stratification. About one-fifth of tumor cells were immunopositive for MIB-1. The MIB-1 positive index of our case was extremely high, compared with that of ordinary papillary carcinoma. This case indicates that biological growth activity in columnar cell carcinoma may be similar to that of undiferentiated carcinoma of the thyroid, since the MIB-1-positive index is close to each other.
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References
Evans, HL Columnar cell carcinoma of the thyroid, a report of two cases of an aggressive variant of thyroid carcinoma. Am J Clin Pathol 85:77–80, 1986.
Akslen LA, Varhaug JE. Thyroid carcinoma with mixed tall-cell and columnar-cell features Am J Clin Pathol 94:442–445, 1990.
Mizukami Y, Nonomura A, Michigishi T, Noguchi M, Nakamura S, Hashimoto T. Columnar cell carcinoma of the thyroid gland, a case report and review of the literature Human Pathol 25:1098–1101, 1994.
Evans HL. Encapsulated columnar-cell neoplasms of the thyroid, a report of four cases suggesting a favorable prognosis. Am J Surg Pathol 20:1205–1211, 1996.
Sobrinho-Simoes M, Nesland JM, Johanessen JV. Columnar cell carcinoma. Another variant of poorly differentiated carcinoma of the thyroid. Am J Clin Pathol 89:264–267, 1988.
Hui P-K, Chan JKC, Cheung PSY, Gwi E. Columnar cell carcinoma of the thyroid. Fine needle aspiration findings in a case. Acta Cytol 34:355–358, 1990.
Flint A, Davenport RD, Lloyd RV. The tall cell variant of papillary carcinoma of the thyroid. Arch Pathol Lab Med 115:169–171, 1991.
Hicks WA, Batsakis JW. Tall cell carcinoma of the thyroid gland. Ann Otol Rhinol Laryngol 102:402, 403, 1993.
Hazard JB. Neoplasia. In: Hazard JB, Smith DE, eds. The thyroid. Baltimore: Williams & Wilkins. 1964; 239–255.
Katoh R, Bray CE, Suzuki K, Komiyama A, Hemmi A, Kawaoi A, Oyama T, Sugai T, Sasou S. Growth activity in hyperplastic and neoplastic human thyroid determined by a immunohistochemical staining procedure using monoclonal antibody MIB-1. Hum Pathol 26:139–146, 1995.
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Hirokawa, M., Shimizu, M., Fukuya, T. et al. Columnar cell carcinoma of the thyroid: MIB-1 immunoreactivity as a prognostic factor. Endocr Pathol 9, 31–34 (1998). https://doi.org/10.1007/BF02739949
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DOI: https://doi.org/10.1007/BF02739949