Abstract
S-adenosyl-L-methionine (SAM) is an important small molecule with many medical interests. The ion-exchange kinetics of SAM+/H+ system with JK110 resin has been studied in this work. The results showed that intra-particle diffusion was the rate limiting step in the ion-exchange process. A suitable model of particle diffusion has been proposed to describe the effects of pH, temperature and SAM concentration in the solution on the ion-exchange rate. By simulating experimental data with model equation, some parameters such as diffusion constant B, internal diffusion coefficient Di and activation energy Ea are obtained.
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References
Alessandra, M., Paola, S., Giovanni, C., Monica, L., Maria, C. and Mario, D. R., “Stabilization of Promoted by Trehalose,”Biochimica et Biophysica Acta,1573, 105 (2002).
Alessandra, M., Lernia, I D., Carteni, M. and Rose, R. D., “Synthesis and Characterization of a New Class of Stable S-Adenosyl-L-Methionine Salts,”International Journal of Pharmaceutics,194, 61 (2000).
Anderer, P., Saletu, B. and Semlitsch, H. V., “Acute and Sub-acute, Double-blind, Placebo-controlled Studies on the Effects of S-adenosyl-L-methionine on Information Processing by ERP-Mapping and LORETA,”International Congress Series,1232, 237 (2002).
Boyd, G. E., Adamson, A. W. and Myers, L. S., “The Exchange Adsorption of Ions from Aqueous Solution by Organic Zeolites. II. Kinetics,”Journal of American Chemical Society,69, 2836 (1947).
Charles, S. L., “Role of S-Adenosyl-L-methionine in the Treatment of Liver Diseases,”Journal of Hepatology,30, 1155 (1999).
Fiecchi, Alberto, US patent, 4028183 (1977).
Ftiedel, H. A., Goa, K. L. and Benfield, P., “S-Adenosyl-L-methionine: A Review of its Pharmacological Properties and Therapeutic Potential in Liver Dysfunction and Affective Disorders in Relation to its Physiological Role in Cell Metabolism,”Drugs,38, 389 (1989).
Farooqui, J., Kim, S. and Paik, W. K., “Measurement of Isoelectric Point S-Adenosyl-L-methionine and its Metabolic Products by an Isoelectric Focusing Technique,”Electrophoresis,4, 261 (1983).
Giulidori, P., Galli-Kienle, M., Katio, E. and Stramentinoli, G., “Trans-methylation, Transulfuration and Aminopropylation Reactions of S-Adenosyl-L-methioninein vivo,”J. Biol. Chem.,259, 4205 (1984).
Hoffman, J. L., “Chromatographic Analysis of the Chiral and Covalent Instability of S-Adenosyl-L-methionine,”Biochemistry,25, 4444 (1986).
Hui, L., “Techniques and Mechanism of the Co-production of S-Adenosyl-L-methionine and Glutathione using the Yeast,” (Doctor Dissertation), Hangzhou: College of Materials Science and Chemical Engineering, Zhejiang University (2002).
Lu, S. C., “S-Adenosyl-L-methionine,”The International Journal of Biochemistry & Cell Biology,32, 391 (2000).
Lu, S. C., “S-Adenosylmethionine,”The International Journal of Biochemistry & Cell Biology,32, 391 (2000).
Mato, J. M., Alvarez, L. and Ortiz, P., “S-Adenosylmethionine Synthesis: Molecular Mechanisms and Clinical Implications,”Pharmacology Therapeutics,73, 265 (1997).
Pascale, R. M., Marras, V., Simile, M. M., Daino, L., Pinna, G., Bennati, S., Carta, M., Seddaiu, M. A., Massarelli, G. and Feo, F., “Chemoprevention of Rat Liver Carcinogenesis by S-Adenosyl-L-methionine: A Long-term Study,”Cancer Res.,52, 4979 (1992).
Selvaraj, R., Younghun, K., Cheol, K. J., Kyunghee, C. and Jongheop, Y., “Batch Adsorptive Removal of Copper Ions in Aqueous Solutions by Ion Exchange Resins: 1200H and IRN97H,”Korean J. Chem. Eng.,21, 187 (2004).
Vettere, G. et al., “Double-blind Comparative Clinical Trial with S-Adenosylmethionine and Indomethacin in the Treatment of Osteoarthritis,”American Journal of Medicine,83(suppl 5A), 78 (1987).
Wei, W., Kramer, P. M. and Siming, Y., “Reversed-phase High-performance Liquid Chromatography Procedure for the Simultaneous Determination of S-Adenosyl-L-methionine and S-Adenosyl-L-homocysteine in Mouse Liver and the Effect of Methionine on their Concentrations,”Journal of Chromatography B,762, 59 (2001).
Yue, T. S. and Wang, Y J., “Study of the Mass Transfer of [HPdCl4]-by Dowex-MAS-1 Macroparaus Anion Exchange Resin,”Journal of Lanzhou University (Natural Sciences),36, 67 (2000).
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Chen, Y., Xu, Z., Shen, W. et al. The ion-exchange kinetics of SAM+/H+ system with JK110 resin. Korean J. Chem. Eng. 22, 121–126 (2005). https://doi.org/10.1007/BF02701473
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DOI: https://doi.org/10.1007/BF02701473