Abstract
Δ6 Desaturase was measured in the mouse brain and liver using linoleic acid as substrate. During pre- and postnatal development, Δ6 desaturase in brain decreased dramatically (12-fold) up to postnatal day 21 and remained nearly constant thereafter. In liver, the activity increased approximately 9-fold between day 3 before birth and day 7 after birth. Then it decreased slightly up to weaning and was approximately constant up to 4 mo. From then on, Δ6 desaturase decreased with age (40% between 4 and 17 mo).
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
Abbreviations
- ATP:
-
adenosine 5′-triphosphate
- b.p.:
-
boiling point
- CoA:
-
eoenzyme A
- KOH:
-
potassium hydroxide
- NADH:
-
reduced NAD (nicotinamide adenine dinudeotide
- NADPH:
-
reduced NADP (NAD phosphate)
References
Brenner, R.R. (1984)Prog. Lipid Res. 23, 69–96.
Farias, R.N. (1980)J. Lipid Res. 17, 251–282.
Mead, J.F. (1984)J. Lipid Res. 25, 1517–1521.
Bourre, J.M., Pascal, G., Durand, G., Masson, M., Dumont, O., and Piciotti, M. (1984)J. Neurochem. 43, 342–348.
Youyou, A., Durand, G., Pascal, G., Piciotti, M., Dumont, O., and Bourre, J.M. (1986)J. Neurochem. 46, 224–228.
Homayoun, P., Durand, G., Pascal, G., and Bourre, J.M. (1988)J. Neurochem. 51, 45–48.
Bourre, J.M., Faivre, A., Dumont, O., Nouvelot, A., Loudes, C., Puymirat, J., and Tixier-Vidal, A. (1983)J. Neurochem. 41, 1234–1242.
Loudes, C., Faivre, A., Barret, A., Grouselle, D., Puymirat, J., and Tixier-Vidal, M. (1983)Dev. Brain. Res. 9, 231–234.
Alling, C., Bruce, A., Karlsson, I., Sapia, O., and Svennerholm, L.J. (1971)J. Nutr. 102, 773–782.
Holman, R.T. (1988)Progr. Chem. Fats and Other Lipids 279–292.
Paoletti, R., and Galli, C. (1972) inLipid, Malnutrition and the Developing Brain (Ciba Foundation Symposium) pp. 121–140, Elsevier, Exempto-Medica, North-Holland, Amsterdam.
Morell, P. (1984) inMyelin. (Morell, P., ed.) Plenum Press, New York and London.
Horrobin, D. (1981)Med. Hyp. 7, 1211–1220.
Strouve-Vallet, C. and Pascaud, M. (1971)Biochimie 53, 699–703.
Cook, H.W. (1978)J. Neurochem. 30, 1327–1334.
Purvis, J., Clandinin, M., and Hacker, R. (1983)Comp. Biochem. Physiol. 75, 199–204.
Sanders, T.A.B., and Rana, S.K. (1987)Ann. Nutr. Metab. 31, 349–353.
Chambaz, J., Ravel, D., Manier, M.C., Pepin, D., Mulliez, N., and Bereziat, G. (1985)Biol. Neonate 47, 136–140.
Carreau, J.P., Mazliak, P., and Frommel, D. (1981)Int. J. Biochem. 13, 831–836.
Crawford, M.A., Hassam, A.G., and Stevens, P.A. (1981)J. Lipid Res. 20, 31–40.
Galli, C., Trzeciak, H., and Paoletti, R. (1971)Biochim. Biophys. Acta 248, 449–454.
Neuringer, M., Anderson, C.J., and Connor, W.E. (1988)Ann. Rev. Nutr. 8, 517–541.
Sinclair, A.J., and Crawford, M.A. (1972)J. Neurochem. 19, 1753–1758.
Cunnane, S.C., Napoleon Keeling, P.W., Thompson, R.P.H., and Crawford, M.A. (1984)British J. Nutr. 51, 209–217.
Horrobin, D.F., Huang, Y.S., Cunnane, S.C., and Manku, M.S. (1984)Lipids 19, 806–811.
Blond, J.P., Lemarchal, P., and Spielmann, D. (1981)C.R. Acad. Sc. Paris, 292, 911–914.
Blond, J.P., and Lemarchal, P. (1984)Reprod. Nutr. Develop. 24, 1–10.
Narce, M., and Poisson, J.P. (1985)C.R. Soc. Biol. 179, 732–740.
Lowry, O.H., Rosebrough, N.J., Farr, A.L., and Randall, R.J. (1951)J. Biol. Chem. 193, 265–275.
Ravel, D., Chambaz, J., Pepin, D., Manier, M.C., and Bereziat, G. (1985)Biochim. Biophys. Acta 833, 161–164.
Carreau, J.P., Daudu, O., Mazliak, P., and Bourre, J.M. (1979)J. Neurochem. 32, 659–660.
Bourre, J.M., Paturneau-Jouas, M., Daudu, O., and Baumann, N.A. (1977)Eur. J. Biochem. 72, 41–47.
Bourre, J.M., Daudu, O., and Baumann, N. (1976)Biochim. Biophys. Acta 424, 1–7.
Author information
Authors and Affiliations
About this article
Cite this article
Bourre, J.M., Piciotti, M. & Dumont, O. Δ6 desaturase in brain and liver during development and aging. Lipids 25, 354–356 (1990). https://doi.org/10.1007/BF02544347
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02544347