Abstract
Norflurazon is a herbicide known to inhibit carotene biosynthesis and linolenic acid biosynthesis in plants. In the present work, the effect of norflurazon on the metabolism of essential fatty acids was studied in isolated rat liver cells and in rat liver microsomes, incubated with [1-14C] labeled linolenic acid (18∶3, n−3), dihomogammalinolenic acid (20∶3, n−6) and eicosapentaenoic acid (20∶5, n−3). Norflurazon (0.1 mM, 1.0 mM) was found to inhibit essential fatty acid desaturation. The Δ6 desaturation is inhibited more efficiently than the Δ5 and Δ4 desaturation. The chain elongation of essential C18 fatty acids to their C20 and C22 homoglogs was not inhibited by norflurazon.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Sandmann, G., and Böger, P. (1982) in Biochemical Responses Induced by Herbicides (Moreland, D.E., St. John, J.B., and Hess, F.D., eds.) ACS Symposium Series, no. 181, pp. 113–130, American Chemical Society, Washington, D.C.
Willemot, C. (1977) Plant Physiol., 60, 1–4.
St. John, J.B. (1976) Plant Physiol. 57, 38–40.
St. John, M.B., and Christiansen, M.N. (1976) Plant Physiol. 57, 257–259.
Thomassen, M.S., Strøm, E., Christiansen, E.N., and Norum, K.R. (1979) Lipids 14, 58–65.
Seglen, P.O. (1973) Exp. Cell. Res. 82, 391–398.
Nordby, G., Berg, T., Nilsson, M., and Norum, K.R. (1976) Biochim. Biophys. Acta 450, 69–77.
Marcell, Y.L., Christiansen, K., and Holman, R.T. (1968) Biochim. Biophys. Acta 164, 25–34.
Christiansen, R. (1977) Biochim. Biophys. Acta 488, 249–262.
Folch, J., Lees, M., and Sloan-Stanley, G.H. (1957) J. Biol. Chem. 226, 497–509.
Metcalf, L.D., and Schmitz, A.A. (1961) Anal. Chem. 33, 363–368.
Hagve, T.A., and Christopherson, B.O. (1984) Biochim. Biophys. Acta 796, 205–217.
Lowry, O.H., Rosebrough, N.J., Farr, A.L., and Randall, R.J. (1959) J. Biol. Chem. 193, 265–275.
Brenner, R.R. (1981) Progr. Lipid Res. 20, 41–47.
Author information
Authors and Affiliations
About this article
Cite this article
Hagve, TA., Christophersen, B.O. & Boger, P. Norflurazon—An inhibitor of essential fatty acid desaturation in isolated liver cells. Lipids 20, 719–722 (1985). https://doi.org/10.1007/BF02534393
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02534393