Abstract
Dehydroepiandrosterone, a mammalian glucose-6-phosphate dehydrogenase inhibitor, preventedA vy/a mice from becoming obese. Decreased accumulation of triacylglycerol accounted for a large portion of the weight difference between treated and controlA vy/a mice. Hepatic lipogenesis as measured by3H2O incorporation into total lipid was less in the dehydroepian drosterone-treated mice. Dehydroepiandrosterone did not suppress appetite and had no apparent toxic effects at the doses used, and its weight controlling effects were reversible upon withdrawal of treatment.
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Yen, T.T., Allan, J.A., Pearson, D.V. et al. Prevention of obesity in Avy/a mice by dehydroepiandrosterone. Lipids 12, 409–413 (1977). https://doi.org/10.1007/BF02533624
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DOI: https://doi.org/10.1007/BF02533624