Abstract
The hydrogen belts of membranes are defined as the regions consisting of hydrogen bond acceptors, i.e., the C=O groups of glycero- and sphingolipids, and hydrogen bond donors, i.e., cholesterol-OH, sphingolipid-OH, proteins, and water. Lipid-lipid hydrogen bonding in these belts has been suggested. The connection of such hypothetical bonding with the condensation effect, i.e., the apparent reduction of surface area occupied by phospholipids in mixed monolayers with cholesterol, has been tested with lipids possessing and lacking C=O groups: diester, diether, and dialkyl phosphatidylcholine, and analogous polyoxyethylene diglycerides. Condensation by cholesterol was observed for all lipids. Consequently, the hypothetical lipid-C=O-cholesterol hydrogen bonding is not a prerequisite for the condensation effect.
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References
Brockerhoff, H., Lipids 9:645 (1974).
Chapman, D., in “Form and Function of Phospholipids,” Edited by G.B. Ansell, J.N. Hawthorne, and R.M.C. Dawson, Elsevier Scientific Publ. Co., Amsterdam, The Netherlands, 1973, p. 117.
Leathes, J.B., Lancet I:853 (1925).
Demel, R.A., L.L.M. Van Deenen, and B.A. Pethica, Biochim. Biophys. Acta 135:11 (1967).
Demel, R.A., K.R. Bruckdorfer, and L.L.M. Van Deenen, Ibid. 255:311 (1972).
de Gier, J., J.B. Mandersloot, and L.L.M. Van Deenen, Ibid. 150:666 (1972).
Scarpa, A., and J. de Gier, Ibid. 241:789 (1971).
de Kruyff, B., R.A. Demel, A.J. Slotboom, L.L.M. van Deenen, and A.F. Rosenthal, Ibid. 307:1 (1973).
Singleton, W.S., M.S. Gray, M.L. Brown, and J.L. White, JAOCS 42:53 (1965).
Brockerhoff, H., in “Methods Enzymology,” Vol. 35, Edited by J.M. Lowenstein, Academic Press, New York, NY 1975, p. 315.
Cubero Robles, E., and D. van den Berg, Biochim. Biophys. Acta 187:520 (1969).
Baumann, W.J., and H.K. Mangold, J. Org. Chem. 31:498 (1966).
Chacko, G.K., and D.J. Hanahan, Biochim. Biophys. Acta 164:252 (1968).
Eibl, H., D. Arnold, H.U. Weltzien, and O. Westphal, Ann. Chem. 709:226 (1967).
Weitzel, G., and J. Wojahn, Z. Physiol. Chem. 285:220 (1950).
Simmons, H.E., and R.D. Smith, JAOCS 81:4256 (1959).
Hooz, J., and S.S.H. Gilani, Can. J. Chem. 46:86 (1968).
Paltauf, F., H. Hauser, and M.C. Phillips, Biochim. Biophys. Acta 249:539 (1971).
Tirri, L.J., P.C. Schmidt, R.K. Pullarkat, and H. Brockerhoff, Lipids 12:000 (1977).
van Deenen, L.L.M., in “Progress in the Chemistry of Fats and Other Lipids,” Vol. VIII, Part 1, Edited by R.T. Holman, Pergamon Press, Oxford, England, 1965, pp. 1–127.
Yeagle, P.L., W.C. Hutton, C. Huang, and R.B. Martin, Proc. Natl. Acad. Sci., USA 72:3477 (1975).
Finer, E.G., and A. Darke, Chem. Phys. Lipids 12:1 (1974).
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Fong, J.W., Tirri, L.J., Deshmukh, D.S. et al. Studies on the hydrogen belts of membranes: I. Diester, diether, and dialkyl phosphatidylcholines and polyoxyethylene glycerides in monolayers with cholesterol. Lipids 12, 857–862 (1977). https://doi.org/10.1007/BF02533276
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DOI: https://doi.org/10.1007/BF02533276