Abstract
Chiral intermediates were prepared by biocatalytic processes for the chemical synthesis of three pharmaceutical drug candidates. These include (i) the synthesis of [(3R-cis)-3-(acetyloxy)-4-phenyl-2-azetidinone2 for the semi-synthesis of paclitaxel (taxol)5, an anticancer compound; (ii) synthesis of chiral (exo,exo)-7-oxabicyclo [2.2.1] heptane-2,3-dimenthanol monoacetate ester9 for the chemoenzymatic preparation of a thromboxane A2 antagonist; (iii) the enzymatic synthesis ofS-(−) 3-benzylthio-2-methylpropanoic acid, a key chiral intermediate for the synthesis of antihypertensive drugs captopril10 or zofenopril13.
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Patel, R.N., Banerjee, A. & Szarka, L.J. Biocatalytic synthesis of some chiral pharmaceutical intermediates by lipases. J Am Oil Chem Soc 73, 1363–1375 (1996). https://doi.org/10.1007/BF02523498
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DOI: https://doi.org/10.1007/BF02523498