Abstract
Background
A slit system for scoring histologic grade and stage has been proposed for the evaluation of renal tissue injury in IgA nephropathy. This grade-stage system (G-S system) represents the histologic analysis of the disease state.
Methods
The first and the subsequent renal biopsy specimens were analyzed using the G-S system in periodic acid methenamine silver stained sections. The sequential change of histologic grade and stage seen in the serial sections was examined to show the natural histologic events occurring during the prolonged course of this disease.
Results
The histologic multiplicity of IgA nephropathy was simplified by subclassifying the findings into 4 groups: low active, active, active sclerosing, and sclerosing. Since the histologic grade represents activity or acuteness of the disease, and stage correlates with sclerosis, the low active group can be expected to be the major population, and the other 3 groups will include cases with more advanced IgA nephropathy.
Conclusion
The G-S system was useful for measuring the disease state of IgA nephropathy. Such a slit system is recommended to aid in the selection of therapy and the follow-up of patients.
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Shigematsu, H. Multiplicity of histopathologic renal lesions in IgA nephropathy: Retrospective analysis of histologic grade and stage in serial biopsy specimens. Clin Exper Neph 2, 137–141 (1998). https://doi.org/10.1007/BF02479935
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DOI: https://doi.org/10.1007/BF02479935