Abstract
To evaluate the effect of operative stress on the tumor growth, thoracotomy and/or laparotomy were performed 48 hours after the inoculation of Sato lung cancer cells in Donryu rats. The survival time, the number of metastatic foci on the surface of the lung and the per cent-area of metastatic foci in the frontal section through the pulmonary hilus were observed. Thoracotomy and laparothoracotomy reduced significantly the survival time as compared with the control but no significant difference was found between the two test groups subjected to operative stress. The number and percent-area of metastatic foci found were inversely related to the length of the survival time.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Buinauskas, P. McDonald, G.O. and Cole, W.H.: Role of operative stress on the resistance of the experimental animal to inoculated cancer cells,Ann. Surg. 148: 642–648, 1958.
Fisher, E.R. and Fisher, B.: Experimental studies on factors influencing hepatic metastases,Cancer. 12: 926–932, 1959.
Foulds, L.: The effect of vital staining on the distribution of the Brown-Pearce rabbit tumor. Tenth Scientific Report on Investigations of the Imperial Cancer Research Fund. Taylor and Francis (London), pp 21–31, 1932.
Goldmann, E.E.: Anatomische Untersuchungen ueber die Verbreitungswege boesartiger Geschwuelste,Beitr. z. klin. Chir. 18: 595, 1897.
Greene, H.S.N.: The heterologous transplantation of human melanomas,Yale J. Biol. and Med. 89: 269–278, 1949.
Hattori, T., Hamai, Y. and Ishii, T.: A new procedure of transabdominal resection of esophagocardial cancer and cervical anastomosis obviating thoracotomy,Jap. J. Surg. 5: 211–221, 1975.
Hattori, T., Hamai, Y., Harada, T., Ikeda, H. and Ikeda, T.: Enhancing effect of thoracotomy and/or laparotomy on the growth of ascitic tumor in rats,Jap. J. Surg. in press.
Jonescu, P.: Ueber das Vorkommen von Geschwuelstzellen in stroemenden Blut von Tieren mit Impftumoren,Ztschr. f. Krebsforsch. 75: 129–142, 1922.
Kaplan, H.S. and Murphy, E.D.: The effect of local roentgen irradiation on the biological behavior of a transplantable mouse carcinoma,J. Natl. Cancer Inst. 9: 407–413, 1949.
Knox, L.C.: The relationship of massage to metastases in malignant tumors.Ann. Surg. 75: 129–142, 1922.
Krebs, C.: The effect of roentgen irradiation on the interrelation between malignant tumors and their hosts,Acta Radiol., Suppl. 8: 1–133, 1929.
Lewis, M.R. and Cole, W.H.: Experimental increase of lung metastases after operative trauma (Amputation of limb with tumor),Arch. Surg. 77: 621–629, 1958.
Lucke, B. and Schlumberger, H.: Induction of metastases of frog carcinoma by increase of environmental temperature,J. Exper. Med. 89: 269–278, 1949.
Marsh, M.C.: Tumor massage and metastases in mice,J. Cancer Res. 11: 101–107, 1927.
Schatten, W.E.: An experimental study of post-operative tumor metastases,Cancer 11: 455–468, 1958.
Wexler, H.: Accurate identification of experimental pulmonary metastases,J. Natl. Cancer Inst. 36: 641–645, 1966.
Author information
Authors and Affiliations
Additional information
Supported in part by Grants-in Aid from the Ministry of Education, Science and Culture and the Ministry of Health and Welfare.
Rights and permissions
About this article
Cite this article
Hattori, T., Hamai, Y., Harada, T. et al. Enhancing effect of thoracotomy and/or laparotomy on the development of the lung metastases in rats after intravenous inoculation of tumor cells. The Japanese Journal of Surgery 7, 263–268 (1977). https://doi.org/10.1007/BF02469360
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02469360