Abstract
The effects of controllable and uncontrollable stress on the receptor binding of dexamethasone in the hypophysis and hippocampus were studied in KHA and KLA rats, lines selected for the ability to development of active escape. Presentation of the controllable stimulus led to a significant reduction in receptor binding of dexamethasone in the hippocampus with significant changes in the plasma corticosterone concentration and receptor binding in the hypophysis. KLA rats were sensitive both to the controllable and the uncontrollable stresses, with increases in plasma corticosterone and receptor binding of dexamethasone in the hypophysis. It is concluded that receptor binding of dexamethasone in the hippocampus and hypophysis depend not only on the behavioral strategy of the animal, but also on the possibility of controlling the situation.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Yu. S. Dmitriev and O. S. Balbukov, “Spontaneous activity in lines of rats selected for different learning abilities,” Zh. Vyssh. Nerv. Deyat.,26, No. 7, 860–862 (1976).
Yu. S. Dmitriev and A. A. Bachmanov, “Features of the behavior of rats selected for learning ability,” Zh. Vyssh. Nerv. Deyat.,42, No. 2, 302–309 (1992).
D. A. Zhukov, “The appearance of ‘learned helplessness’ in rats with different active escape abilities,” Fiziol. Zh. im. I. M. Sechenova,78, No. 12, 64–69 (1992).
V. V. Rakitskaya, I. A. Gagarina, N. G. Lopatina, et al., “Receptor binding of3H-corticosterone in the striatum of rats with a predisposition to audiogenic convulsions,” Fiziol. Zh. im. I. M. Sechenova,76, No. 6, 802–806 (1990).
L. Yu. Ryzhova, D. A. Kulagin, and N. G. Lopatina, “The correlated variability of movement activity and emotionality during the selection of rats for high and low levels of conditioned active escape reflexes,” Genetika,19, No. 1, 121–125 (1983).
B. Bohus, R. F. Benus, D. S. Fokkema, et al., “Neuroendocrine states and behavioral and physiological stress responses,” Progress in Brain Research, E. R. De Kloet, V. M. Weigant, and D. De Wied (eds.), Amsterdam,72, 57–70 (1987).
M. F. Dallman, S. F. Akana, C. S. Cascio, et al., “Regulation of ACTH secretion: variation on a theme of B,” Progr. Hormone Res.,43, 113–173 (1987).
L. Jacobson and R. Sapolsky, “The role of the hippocampus in feedback regulation of the hypothalamo-pituitary-adrenocortical axis,” Endocrine Rev.,12, 118–134 (1991).
E. R. De Kloet, A. Ratka, J. M. H. M. Reul, et al., “Corticosteroid receptor types in brain: regulation and putative function,” Ann N.Y. Acad Sci.,512, 351–361 (1987).
E. R. de Kloet, “Brain corticosteroid receptor balance and homeostatic control,” Front. Neuroendocrin,12, 95–164 (1991).
E. R. de Kloet, M. Oitzl, and M. Joels, “Corticosteroid receptor diversity in hippocampus. Neuronal activity and spatial learning,” in: Stress: Neuroendocrine and Molecular Approaches, R. Kventnansky, R. McCarty, and J. Axelrod (eds.), New York (1992), pp. 735–749.
B. S. McEwen, R. E. Brinton, H. M. Chao, et al, “The hippocampus: a site for modulatory interaction between steroid hormones, neurotransmitters and neuropeptides,” Neuroendocrine Perspectives, E. E. Muller and R. M. MacLeod (eds.),8, 93–132 (1990).
F. R. Patachiolli, P. Casolini, S. Puglisi-Allegra, et al., “Hippocampal glucocorticoid receptors and behavior. A correlative study in rats and mice,” J. Steroid Biochem. Molec. Biol.,37, 405–405 (1990).
R. Sapolsky, L. Krey, and B. S. McEwen, “The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis,” Endocr. Rev.,7, 284–301 (1986).
R. Sapolsky, L. Krey, and B. S. McEwen, “The adrenocortical axis in the aged rat: impaired sensitivity to both fast and delayed feedback inhibition,” Neurobiol. Aging.7, 331–335 (1986).
R. L. Spencer, E. A. Young, P. H. Choo, and B. S. McEwen, “Adrenal steroid type I and type II receptor binding. Estimates ofin vivo receptor number, occupancy and activation with varying levels of steroid,” Brain Res.,514, 37–48. (1990).
M. Veldhuis and E. R. de Kloet, “Vasopressin-related peptides increases the hippocampal corticosterone receptor capacity of diabetes insipidus (Brattleboro rat),” Endocrinol.,7, 331–335 (1982).
D. A. Zhukov, “Strain-dependent escape deficit in two rat models of learned helplessness,” Physiol. Behav.,53, 905–909 (1993).
D. A. Zhukov, “The dexamethasone suppression test in genetically different rats, exposed to inescapable and escapable electric shocks,” Psychoneuroendocrinology,18, 467–474 (1993).
D. A. Zhukov, “The dexamethasone suppression test and brain glucocorticoid receptors in the rat with learned helplessness,” in: Proc. XXIII Congress of the International Society of Psychoneuroendocrinology, USA (1992).
Additional information
Laboratory of Endocrine System Physiology and Pathology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, 199034 St. Petersburg. Translated from Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 82, No. 2, pp. 50–54, February, 1996.
Rights and permissions
About this article
Cite this article
Ordyan, N.É., Zhukov, D.A. Effects of controllable and uncotrollable stresses on the receptor binding of dexamethasone in the hypophysis and hippocampus of rats with different behavior strategies. Neurosci Behav Physiol 28, 22–25 (1998). https://doi.org/10.1007/BF02461907
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02461907