Summary
Quantitative histomorphometric and microradiographic analysis of iliac crest bone biopsy specimens of 10 unselected and untreated postmenopausal women with osteoporosis was performed and the results were correlated with the values measured by osteodensitometry on the right forearm. No positive correlation between histomorphometry or microradiography and osteodensitometry was observed. Moreover, the data of various histomorphometric parameters and those of the bone mineral content measured by microradiography revealed a significant negative correlation when compared to the values obtained by osteodensitometry. Our results suggest, that evaluation of one skeletal site is not necessarily representative of the entire skeleton in patients with postmenopausal osteoporosis.
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Kruse HP, Kuhlencordt F, Ringe JD (1975) Correlation of clinical densitometry and histomorphometric data in osteoporosis. In: Proceedings of the 11th European Symposium on Calcified Tissues Nielsen SP, and Hyørting-Hansen E (eds) Fadl's Forlag, Copenhagen Calcif Tissues 457–461
Burkhardt R (1966) Präoperative Voraussetzungen zur klinischen Histologie des menschlichen Knochenmarkes. Blut 14:30–45
Burkhardt R (1970) Farbatlas der klinischen Histopathologie von Knochenmark und Knochen. Springer-Verlag, Berlin Heidelberg New York
Schenk RK (1965) Zur histologischen Verarbeitung von unentkalktem Knochen. Acta Anat (Basel) 60:3–19
Merz WA, Schenk RK (1970) Quantitative structural analysis of human cancellous bone. Acta Anat (Basel) 75:54–66
Eschberger J, Hartenstein H (1977) Bestimmung der quantitativen Verteilung von Hydroxylapatit im Knochengewebe. Mikroskopie 33:2–10
Wahner HW, Riggs BL, Beabout JW (1977) Diagnosis of osteoporosis: Usefulness of photone absorption of the radius. J Nucl Med 18:432–437
Delling G (1975) Endokrine Osteopathien Büngeler W, Eder M, Lennert K, Peters G, Sandritter W, Seifert G, (eds) Gustav Fischer Verlag, Stuttgart
Ellis HA, Peart KM (1972) Quantitative observations on mineralized and nonmineralized bone in the iliac crest. J Clin Path 25:277–278
Krempien B, Lemminger FM, Ritz E, Weber E (1978) The reaction of different skeletal sites to metabolic bone disease: A micromorphometric study. Klin Wochenschr 56:759
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Kovarik, J., Willvonseder, R., Plenk, H. et al. Evidence for negative correlation between quantitative histological studies and microradiography of iliac crest bone and forearm osteodensitometry in elderly women with osteoporosis. Calcif Tissue Int 34, 456–458 (1982). https://doi.org/10.1007/BF02411284
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DOI: https://doi.org/10.1007/BF02411284