Summary
Examination of the pigment epithelium of older men reveals various changes within the cell which should be regarded as degenerative. The morphologic changes consist of:
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1.
different-sized vesciles or vacuoles, which occur in groups or throughout the cytoplasm of the cell;
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2.
phagosomes, phagocytized parts of the outer segments;
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3.
giant membrane structures which sometimes show a continuous transition into the lateral cell membrane;
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4.
conglomerations of the long lamellae of ergastoplasm covering a huge area of the cell, and
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5.
round, homogeneous electron-dense bodies resembling the lipoid bodies in the normal pigmented epithelial cell of the rabbit.
Zusammenfassung
Im Pigmentepithel älterer Menschen lassen sich verschiedene Strukturen nachweisen, die als degenerative Zeichen aufzufassen sind. Hierbei handelt es sich um
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1.
verschieden große Bläschen und Vacuolen, die einzeln oder zu Gruppen zusammengeschlossen im Cytoplasma der Zelle vorkommen,
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2.
sog. Phagosomen, phagocytierte Abschnitte ehemaliger Außenglieder,
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3.
auffallende Membraneinfaltungen, die mit den seitlichen Zellmembranen in Zusammenhang stehen,
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4.
ausgeprägte Ergastoplasmalamellen, die große Areale der Zellen einnehmen,
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5.
homogene, rundliche, elektronendichte Körperchen, die den Lipoidablagerungen im normalen Pigmentepithel der Kaninchenretina ähneln.
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Mit dankenswerter Unterstützung durch die Deutsche Forschungsgemeinschaft.
Auszugsweise vorgetragen auf dem 4. Kongreß der Europäischen Gesellschaft für Ophthalmologie, Budapest 1972.
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Lerche, W. Elektronenmikroskopische Untersuchungen über Strukturveränderungen im Pigmentepithel der menschlichen Retina. Albrecht von Graefes Arch. Klin. Ophthalmol. 189, 323–338 (1974). https://doi.org/10.1007/BF02384858
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DOI: https://doi.org/10.1007/BF02384858