Abstract
The immunoglobulin-related chains of cell-surface receptors for the Fc region of immunoglobulins (FCERIα, FcγRI, FcγRII, and FcγRIIIα) are encoded by members of a gene family. Phylogenetic analysis of representative members of this family from mammals revealed that FcγRIIIα genes of human, mouse, and rat are not orthologous to one another in the region of the gene encoding the Immunoglobulin C2-set domains. In phylogenetic trees of this region, FcγRIIIα and FcγRII clustered together. However, in trees based on both coding and noncoding regions 5′ and 3′ to the C2 domains, FcγRIIIα genes of human, mouse, and rat clustered together. This pattern of relationship is most easily explained as a result of two independent recombinational events occurring in the mouse and rat after these two species diverged, in each of which the exons encoding the C2 domains were donated to an FcγRIIIα gene by an FcγRII gene.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Barclay AN, Beyers AD, Birkeland ML, Brown MH, Davis SJ, Somoza C, Williams AF (1993) The leucocyte antigen factsbook. Academic Press, London
Farber DL, Giorda R, Nettleton MY, Trucco M, Kochan JP, Sears DW (1993) Rat class IIIFcγ receptor isoforms differ in IgG subclass-binding specificities and fail to associate productively with CD3ζ. J Immunol 150:4364–4375
Felsenstein J (1985) Confidence limits on phylogenies: an approach using the bootstrap. Evolution 39:783–791
Fridman WH, Bonnerot C, Daeron M, Amigorena S, Teillaud J-L, Sautes C (1992) Structural basis of Fcy receptor functions. Immunol Rev 125:49–75
Higgins DG, Bleasby AJ, Fuchs R (1992) Clustal V: improved software for multiple sequence alignment. Comput Appl Biosci 8:189–191
Hogarth PM, Witost E, Hulett MD, Bonnerot C, Even J, Fridman WH, McKenzie IFC (1991) Structure of the mouse βFcγ receptor II gene. J Immunol 146:369–376
Hogarth PM, Hulett MD, Ierino FL, Tate B, Powell MS, Brinkworth RI (1992) Identification of the immunoglobulin binding regions (IBR) of FcγRII and FcεRI. Immunol Rev 125:21–35
Hughes AL (1994) The evolution of functionally novel proteins after gene duplication. Proc R Soc Lond [Biol] 256:119–124
Hulett MD, Hogarth PM (1994) Molecular basis of Fc receptor function. Immunol 57:1–127
Jukes TH, Cantor CR (1969) Evolution of protein molecules. In: Munro HN (ed) Mammalian protein metabolism. Academic Press, New York, pp 21–132
Kumar S, Tamura K, Nei M (1993) MEGA: molecular evolutionary genetic analysis, version 2.0. Pennsylvania State University, University Park
Lanier L, Yu G, Phillips JH (1989) Co-association of CD3ζ with a receptor (CD16) for IgG Fe on human natural killer cells. Nature 342:803–806
Li W-H (1983) Evolution of duplicate genes and pseudogenes. In: Nei M, Koehn RK (eds) Evolution of genes and proteins. Sinauer, Sunderland, MA, pp 14–37
Maliszeski CR, March CJ, Schoenborn MA, Gimpel S, Shen L (1990) Expression cloning of a human Fc receptor for IgA. J Exp Med 172:1665–1672
Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HHQ, Tsu L-C, Shi X, George SR, O'Dowd B (1994) Cloning of human genes encoding novel G protein-coupled receptors. Genomics 23:609–618
Nei M (1987) Molecular evolutionary genetics. Columbia University Press, New York
Nei M, Gojobori T (1986) Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitution. Mol Biol Evol 3:418–426
Ohno S (1973) Ancient linkage groups and frozen accidents. Nature 244:259–262
Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV (1990) Organisation of the human and mouse low-affinity FcγR genes: duplication and recombination. Science 248:732–735
Ravetch JV, Kinet J-P (1991) Fc receptors. Annu Rev Immunol 9:457–492
Rzhetsky M, Nei M (1992) A simple method for estimating and testing minimum-evolution trees. Mol Biel Evol 9:945–967
Saitou N, Nei M (1987) The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol 4:406–425
Sandberg K, Ji H, Clark AIL, Shapira H, Catt KJ (1992) Cloning and expression of a novel angiotensin II receptor subtype. J Biol Chem 267:9455–9458
Swofford DL (1990) PAUP: phylogenetic analysis using parsimony. Illinois Natural History Survey, Champaign
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hughes, A.L. Gene duplication and recombination in the evolution of mammalian Fc receptors. J Mol Evol 43, 4–10 (1996). https://doi.org/10.1007/BF02352293
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02352293