Abstract
A 2-year-old boy with acute lymphoblastic leukemia and neutropenia on intensive induction chemotherapy, developed a necrotizing skin lesion under an armboard used to stabilize an intravenous line. The necrotizing skin lesion was refractory to itraconazole and fluconazole therapy, and the skin biopsy and cultures grewAbsidia corymbifera as the etiologic organism on day 26. Since the organism was highly susceptible to amphotericin B, he was treated with systemic and local amphotericin B as well as granulocyte colony-stimulating factor (G-CSF) followed by debridement of the ulcerated lesion and skin grafting. The zygomycotic lesion cleared on day 45. There was no evidence of recurrent fungal disease. Systemic and local amphotericin B and G-CSF were effective in clearing the skin lesion. We would like to emphasize that meticulous local hygiene and frequent inspection of covered areas is of great importance in preventing skin lesions by such nonvirulent environmental fungi. The use of G-CSF should also be included in the treatment regimen of primary cutaneous zygomycosis in neutropenic patients.
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Kawasaki, H., Yoshimura, K., Kohdera, U. et al. Primary cutaneous zygomycosis due toAbsidia corymbifera in a child with acute leukemia. Int J Clin Oncol 1, 118–120 (1996). https://doi.org/10.1007/BF02348278
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DOI: https://doi.org/10.1007/BF02348278