Abstract
Background
Among 167 patients with endometrial carcinoma, 21 (12.6%) appeared to have a concomitant ovarian malignancy. Three groups were defined by tumor histology. Group A was defined as endometrial and ovarian carcinomas of dissimilar histology. Group B was defined as both carcinomas with the same histologic type, but with benign and/or borderline malignant lesions adjacent to the ovarian malignancy. Group C was defined as the same carcinomas without benign or borderline lesions.
Methods
Based on these 3 groups the endometrial carcinomas with synchronous ovarian malignancies were analyzed histo- and clinico-pathologically.
Results
Four of the 21 cases (19.0%) were placed into group A, 7 of the 21 (33%) in group B, and 10 of the 21 (47.7%) in group C. Groups A and B, which were diagnosed as double primary cancers based on histological features, had a frequency of 52.4%, whereas group C, which was diagnosed as mostly metastatic, had a frequency of 47.6%. The highest frequency of deep myometrial invasion was found in group C. The highest incidence of lymph node metastasis was in group B. Enlarged ovaries with malignant lesions appeared in 100% of group A patients, in 88.9% of group B patients and in 16.7% of group C patients. In contrast, the frequency of normal-sized ovaries was highest in group C at 83.3%. There were no statistical differences in age, chief complaints and peritoneal cytology. The survival rates for groups A, B, and C were 75%, 66.7%, and 33.3%, respectively. The survival curve for group C was comparatively lower than those for groups A and B.
Conclusion
These data suggest that the histological findings of benign and/or borderline malignant lesions in ovarian tumors, in addition to ovarian size, are useful in the differentiation between independent and metastatic carcinomas of the endometrium.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Annegers JF, Malkasian GD. Patterns of other neoplasia in patients with endometrial carcinoma. Cancer 1981;48:856–859.
Schwartz Z, Ohel G, Birkenfeld A, Anteby SO, Schenker G. Second primary malignancy in endometrial carcinoma patients. Gynecol Oncol 1985;22:40–45.
Axelrod JH, Fruchter R, Boyce JG. Multiple primaries among gynecologic malignancies. Gynecol Oncol 1984;18:359–372.
Offutt SR. Relationship of carcinoma of the body of the uterus of the ovaries. Surg Gynecol Obstet 1932:490–494.
Eisner RF, Nieberg RK, Berek JS. Synchronous primary neoplasms of the female reproductive tract. Gynecol Oncol 1989;33:335–339.
Silverman BB, O'Neill RT, Mikuta JJ. Multiple malignant tumors associated with primary carcinoma of the ovary. Surg Gynecol Obstet 1972;134:244–248.
Russell P, Bannatyne PM, Solomon HJ, Stoddard LD, Tattersall MHN. Multifocal tumorigenesis in the upper female genital tract-implications for staging and management. Int J Gynecol Pathol 1985;4:192–210.
Kuramoto H, Jobo T, Tuchiya M. Double cancer in gynecologic field. Jpn Obstet Gynecol Pract 1985;34:1125–1131.
Somekawa Y, Kubota T, Ozaki Y, Kuwae C, Saito M. A study of double cancer of the ovary and endometrium. Tokyo district. J Jpn Obstet Gynecol 1985;34:395–398.
Deligdisch L, Szulman AE. Multiple and multifocal carcinomas in female genital organs and breast. Gynecol Oncol 1975;3:181–190.
Kline RC, Wharton JT, Atkinson EN, Burke TW, Gershenson DM, Edowards CL. Endometrioid carcinoma of the ovary: retrospective review of 145 cases. Gynecol Oncol 1990;39:337–346.
Tidy J, Mason WP. Endometrioid carcinoma of the ovary: a retrospective study. Br J Obstet Gynecol 1988;95:1165–1169.
Czernobilsk B, Silverman BB, Mikuta JJ. Endometrioid carcinoma of the ovary: a clinicopathologic study of 75 cases. Cancer 1970;26:1141–1152.
Lauchlan SC. The secondary Müllerian system. Obstet Gynecol 1972;27:133–146.
Eifel P, Hendrickson M, Ross J, Ballon S, Martinez A, Kempson R. Simultaneous presentation of carcinoma involving the ovary and the uterine corpus. Cancer 1982;50:163–170.
Billroth T. General Surgery; Pathology and Therapeutics. New York: Appleton Century Crofts, 1979.
Warren S, Gates O. Multiple primary malignant tumors; a survey of the literature and a statistical study. Am J Cancer 1932;16:1358–1414.
Ulbright TM, Roth LM. Metastatic and independent cancers of the endometrium and ovary; a clinicopathologic study of 34 cases. Hum Pathol 1985;16:28–34.
Russell P, Bannatyne P. Surgical Pathology of the Ovaries. New York: Churchill Livingstone, 1989:236–252.
Zaino RJ, Unger ER, Whitney C. Synchronous carcinomas of the uterine corpus and ovary. Gynecol Oncol 1984;19:329–335.
Woodruff D, Solomon D, Sullivan H. Multifocal disease in the upper genital canal. Obstet Gynecol 1985;65:695–698.
Jobo T, Okawara S, Hayashi R, Morisawa T, Ouno E, Kramoto H, Nishijima M. Clinicopathological analysis of well differentiated endometrial adenocarcinoma. Pathol Clinic Med 1992;10:413–419.
Author information
Authors and Affiliations
About this article
Cite this article
Kamikatahira, S., Jobo, T. & Kuramoto, H. Endometrial carcinoma with synchronous ovarian malignancy-differentiation between independent and metastatic carcinomas. Int J Clin Oncol 1, 100–108 (1996). https://doi.org/10.1007/BF02348275
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02348275