Abstract
Transmembrane 4 superfamily (TM4SF) molecules are predominantly mammalian cell surface glycoproteins that are thought to transduce signals mediating cell development, activation, and motility. Analysis of the Genpept sequence database reveals YKK8, a novel member of the TM4SF in the nematode,Caenorhabditis elegans. YKK8 is a putative 27.4-kDa protein encoded by a gene on chromosome III of theC. elegans genome (Wilson et al. [1994]Nature 368:32–38). The assignment of YKK8 to the TM4SF is justified by three criteria: statistical comparison of protein sequences, conserved TM4SF protein sequence motifs, and conserved TM4SF intron/exon boundaries in the genomic sequence. The discovery of a TM4SF molecule in the nematode extends this superfamily to a more primitive branch of the phylogenetic tree and suggests a fundamental role for TM4SF molecules in biology.
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Correspondence to: M.G. Tomlinson
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Tomlinson, M.G., Wright, M.D. A new transmembrane 4 superfamily molecule in the nematode,Caenorhabditis elegans . J Mol Evol 43, 312–314 (1996). https://doi.org/10.1007/BF02338840
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DOI: https://doi.org/10.1007/BF02338840