Abstract
The evolution of the Metalloproteinase Disintegrin Cysteine-rich (MDC) gene family and that of the mammalian Matrix-degrading Metalloproteinases (MMPs) are compared. The alignment of snake venom and mammalian MDC and MMP precursor sequences generated a phylogenetic tree that grouped these proteins mainly according to their function. Based on this observation, a common ancestry is suggested for mammalian and snake venom MDCs; it is also possible that gene duplication of the already-assembled domain structure, followed by divergence of the copies, may have significantly contributed to the evolution of the functionally diverse MDC proteins. The data also suggest that the structural resemblance of the zinc-binding motif of venom MDCs and MMPs may best be explained by common ancestry and conservation of the proteolytic motifs during the divergence of the proteins rather than through convergent evolution.
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Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ (1990) Basic local alignment search tools. J Mol Biol 215:403–410
Bjarnason JB, Fox JW (1994) Hemorrhagic metalloproteinases from snake venoms. Pharmacol Ther 62:325–372
Blobel CP, Wolfsberg TG, Turck CW, Myers DG, Primakoff P, White JM (1992) A potential fusion peptide and integrin ligand domain in a protein active in sperm-egg fusion. Nature 356:248–252
Blundell TL (1994) Metalloproteinase superfamilies and drug design. Nat Struc Biol 1:73–75
Creigton TE, Darby NJ (1989) Functional evolutionary divergence of proteolytic enzymes and their inhibitors. Trends Biochem Sci 14: 319–324
Daltry AA, Wüster W, Thorpe RS (1996) Diet and snake venom evolution. Nature 379:537–540
Dayhoff MO, Schartz RM, Orcutt BC (1978) Atlas of protein sequence and structure, vol 5, supplement 3. NBRF, Washington, p 345
De Souza SJ, Brentani R (1993) Sequence homology between a bacterial metalloproteinase and eukaryotic matrix metalloproteinases. J Mol Evol 36:596–598
Emi M, Katagid T, Harada Y, Saito H, Inazawa J, Ito I, Kasumi, F, Nakamura Y (1993) A novel metalloprotease/disintegrin-like gene at 17g213 is somatically rearranged in two primary breast cancers. Nat Genet 5:151–157
Felsenstein J (1985) Confidence limits on phylogenies: an approach using the bootstrap. Evolution 39:783–791
Genetics Computer Group (1991) Program manual for the GCG package, Version 7. 575 Science Drive, Madison, WI 53711, USA
Gomis-Ruth FX, Kress LF, Bode W (1993) First structure of a venom metalloproteinase: a prototype for matrix metalloproteinases/collagenases EMBO J 12:4151–4157
Gould RJ, Polokoff MA, Friedman PA, Huang TF, Holt JC, Cook JJ, Niewarowski S (1990) Disintegrins—a family of integrins inhibitory proteins from viper venoms. Proc Sue Exp Biol Med 5:168–171
Higgins DG, Sharp PM (1989) Fast and sensitive multiple sequence alignments on a microcomputer. Comput Appl Biosci 5:151–153
Higgins DG, Bleasby AJ, Fuchs R (1992) Cluster V: improved software for multiple sequence alignment. Comput Appl Biosci 2: 189–191
Huang TF, Holt JC, Kirby EP, Niewiarowski S (1989) Trigramin—primary structure and its inhibition of von Willebrand factor binding to glycoprotein IIB/IIIA complex on human platelets. Biochemistry 28:661–666
Ikeo K, Takahashi K, Gobori T (1995) Different evolutionary history of kringle and protease domains in serine proteases: a typical example of domain evolution. J Mol Evol 40:331–336
Jongeneel CV, Bouvier J, Bairoch A (1989) A unique signature identifies a family of zinc-dependent metallopeptidases. FEBS Lett 242: 211–214
Moura-da-Silva AM, Paine MJI, Diniz MRV, Theakston RDG, Crampton JM (1995) The molecular cloning of a phospholipase A2 fromBothrops jararacussu venom: evolution of venom Group II PLA2's may imply gene duplication. J Mol Evol 41:174–179
Ohta T (1994) On hypervadability at the reactive center of proteolytic enzymes and their inhibitors. J Mol Evol 39:614–619
Paine MJI, Desmond HP, Theakston RDG, Crampton JM (1992) Purification, cloning and molecular characterization of a high molecular weight haemorrhagic metalloprotease, jararhagin, fromBothrops jararaca venom. J Biol Chem 267:22869–22876
Paine MJI, Moura da Silva AM, Theakston RDG, Crampton JM (1994) Cloning of metalloproteinase genes in carpet viper (Echis pyramidum leakeyi): further members of the metalloproteinase/disintegrin gene family. Eur J Biochem 224:483–488
Perry ACF, Jones R, Barker PJ, Hall L (1992) A mammalian epididymal protein with remarkable sequence similarity to snake venom hemorrhagic peptides. Biochem J 286:671–675
Saitou N, Nei M (1987) The neighbour-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol 4:406–425
Weskamp G, Blobel CP (1994) A family of cellular proteins related to snake venom disintegrins. Proc Natl Acad Sci USA 91:2748–2751
Woessner JF (1991) Matrix metalloproteinases and their inhibitors in connective-tissue remodelling. FASEB J 5:2145–2154
Wolfsberg TG, Bazan JF, Blobel CP, Myles DG, Primakoff P, White JM (1993) The precursor region of a protein active in sperm-egg fusion contains a metalloproteinase and disintegrin domain: structural, functional, and evolutionary implications. Proc Natl Acad Sci USA 90:10783–10787
Yoshida S, Setoguchi M, Higuchi Y, Akizuki S, Yamamoto S (1990) Molecular cloning of a cDNA encoding MS2 antigen, a novel cell surface antigen strongly expressed in routine monocytic lineage. Int Immunol 2: 586–591
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Correspondence to: J.M. Crampton
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Moura-da-Silva, A.M., Theakston, R.D.G. & Cramptonl, J.M. Evolution of disintegrin cysteine-rich and mammalian matrix-degrading metalloproteinases: Gene duplication and divergence of a common ancestor rather than convergent evolution. J Mol Evol 43, 263–269 (1996). https://doi.org/10.1007/BF02338834
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DOI: https://doi.org/10.1007/BF02338834