Abstract
This study reports our experience with low-dose prostaglandin E1 (PGE1) treatment of 91 newborns with ductus dependent congenital heart disease (CHD). PGE1 efficacy, side-effects as well as the cardiovascular and respiratory profile of the patients were analysed. PGE1 doses > 0.02 μg/kg per minute were used for only 5.3% of the total 23 656 h of treatment. The mean systolic blood pressures did not differ from the normal mean for patients with cyanotic CHD, while the diastolic values were lowered. Respiratory support was required only during 13.7% of the total treatment time. Apnoeas occurred in 21 (38%) of the 55 spontaneously breathing infants, who all had a cyanotic CHD. The incidence of apnoeas was lower during treatment with doses < 0.01 μg/kg per minute.
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Abbreviations
- BAS :
-
balloon atrial septostomy
- CHD :
-
congenital heart disease
- PGE 1 :
-
prostaglandin E1
- SD :
-
standard deviation
- SO 2 :
-
oxygen saturation
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Kramer, HH., Sommer, M., Rammos, S. et al. Evaluation of low dose prostaglandin E1 treatment for ductus dependent congenital heart disease. Eur J Pediatr 154, 700–707 (1995). https://doi.org/10.1007/BF02276712
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DOI: https://doi.org/10.1007/BF02276712