Abstract
In order to evaluate the action of central nervous system Corticotropin-Releasing Factor (CRF) in the control of feeding behavior the present studies employed a dietary self-selection task sensitive both to overall appetite as well as preferential intake of familiar versus unfamiliar foods. Prior to the diet selection test, one group of nutritionally stressed animals was fed a protein deficient diet in order to increase the preference for unfamiliar foods relative to nutritionally replete subjects. Both CRF (0.05 and 0.5 µg ICV) and physical restraint (30 min) attenuated selectively the consumption of a novel food choice by deficient animals without affecting concurrent intake of familiar food. Further, CRF administration did not alter water intake or consumption of either diet by the replete control group suggesting that the peptide produced a stress dependent, enhanced response to novelty without a general effect on appetite. The CRF antagonist,α-helical CRF9–41 (1, 5 and 25 µg ICV), increased familiar diet consumption in nutritionally deficient subjects without affecting the self-selection pattern or replete controls. Chlordiazepoxide (5 mg/kg) also increased selectively the intake of familiar food suggesting that this action is the anxiolytic complement of the effect of stress in this paradigm. The CRF antagonist (5 and 25 µg) reversed the anorexia produced by CRF (0.5 µg) as well as that induced by restraint stress. These results favor a direct role for endogenous CRF systems in coordinating the behavioral responses to dietary stress.
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Arase K, York DA, Shimizu H, Shargill N, Bray GA (1988) Effects of corticotropin-releasing factor on food intake and brown adipose tissue thermogenesis in rats. Am J Physiol 255:E255-E259
Baldwin HA, Britton KT, Koob GF (1990) Behavioral effects of corticotropin-releasing factor. Current topics in neuroendocrinology, vol. 10. Springer, Berlin Heidelberg New York, pp 1–14
Berridge CW, Dunn AJ (1987) A corticotropin-releasing factor antagonist reverses the stress-induced changes of exploratory behavior in mice. Horm Behav 21:393–401
Berridge CW, Dunn AJ (1989a) CRF and restraint-stress decrease exploratory behavior in hypophysectomized mice. Pharmacol Biochem Behav 34:517–519
Berridge CW, Dunn AJ (1989b) Restraint-stress-induced changes in exploratory behavor appear to be mediated by norepinephrine-stimulated release of CRF. J Neurosci 9[10]:3513–3521
Bodnoff SR, Suranyi-Cadotte B, Aitken DH, Quirion R, Meaney MJ (1989) Role of the central benzodiazepine receptor system in behavioral habituation to novelty. Behav Neurosci 103:209–212
Britton DR, Koob GF, Rivier J, Vale W (1982) Intraventricular corticotropin-releasing factor enhances behavioral effects of novelty. Life Sci 31:363–367
Britton KT, Morgan J, Rivier J, Vale W, Koob GF (1985) Chlordiazepoxide attenuates response suppression induced by corticotropin-releasing factor in the conflict test. Psychopharmacology 86:170–174
Britton KT, Lee G, Dana R, Risch SC, Koob GF (1986a) Activating and ‘anxiogenic’ effects of corticotropin releasing factor are not inhibited by blockade of the pituitary-adrenal system with dexamethasone. Life Sci 39:1281–1286
Britton KT, Lee G, Vale W, Rivier J, Koob GF (1986b) Corticotropin releasing factor (CRF) receptor antagonist blocks activating and ‘anxiogenic’ actions of CRF in the rat. Brain Res 369:303–306
Brown MR, Fisher LA, Spiess J, Rivier C, Rivier J, Vale W (1982) Corticotropin-releasing factor: actions on the sympathetic nervous system and metabolism. Endocrinology 111[3]o:928–932
Cooper SJ (1980) Effects of chlordiazepoxide and diazepam on feeding performance in a food-preference test. Psychopharmacology 69:73–78
Cooper SJ (1989) Benzodiazepine receptor-mediated enhancement and inhibition of taste reactivity, food choice, and intake. Ann NY Acad Sci 575:321–337
Cooper SJ, Burnett G, Brown K (1981) Food preference following acute or chronic chlordiazepoxide administration: tolerance to an antineophobic action. Psychopharmacology 73:70–74
Deutsch JA, Moore BO, Heinrichs SC (1989) Unlearned specific appetite for protein. Physiol Behav 46:619–624
Drewnowski A, Halmi KA, Pierce B, Gibbs J, Smith GP (1987a) Taste and eating disorders. Am J Clin Nutr 46:442–450
Drewnowski A, Bellisle F, Aimez P, Remy B (1987b) Taste and bulimia Physiol Behav 41:621–626
Dunn AJ, Berridge CW (1990) Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses? Brain Res Rev 15:71–100
Eaves M, Britton KT, Rivier J, Vale W, Koob GF (1985) Effects of corticotropin releasing factor on locomotor activity in hypophysectomized rats. Peptides 6:923–926
Eysenck HJ, Broadhurst PL (1964) Introduction. In: Eysenck HJ (ed) Experiments in motivation. Pergamon Press, Oxford, pp 285–291
Gosnell BA, Morley JE, Levine AS (1983a) A comparison of the effects of corticotropin releasing factor and sauvagine on food intake. Pharmacol Biochem Behav 19:771–775
Gosnell BA, Morley JE, Levine AS (1983b) Adrenal modulation of the inhibitory effect of corticotropin releasing factor on feeding. Peptides 4:807–812
Heinrichs SC, Britton KT, Koob GF (1991) Both conditioned taste preference and aversion induced by corticotropin-releasing factor. Pharmacol Biochem Behav 40:717–721
Kaye WH, Berrittini WH, Gwirtsman HE, Gold PW, George DT, Jimerson DC, Ebert MH (1989) Contribution of CNS neuropeptide (NPY, CRH, and Beta-Endorphin) alterations to psychophysiological abnormalities in anorexia nervosa. Psychopharmacol Bull 25[3]:433–438
Krahn DD, Gosnell BA (1989) Corticotropin-releasing hormone: possible role in eating disorders. Psychiatr Med 7[4]:235–245
Krahn DD, Gosnell BA, Grace M, Levine AS (1986) CRF antagonist partially reverses CRF- and stress-induced effects on feeding. Brain Res Bull 17:285–289
Krahn DD, Gosnell BA, Levine AS, Morley JE (1988) Behavioral effects of corticotropin-releasing factor: localization and characterization of central effects. Brain Res 443:63–69
Levine AS, Rogers B, Kneip J, Grace M, Morley JE (1983) Effect of centrally administered corticotropin releasing factor (CRF) on multiple feeding paradigms. Neuropharmacology 22[3A]:337–339
Morley JE, Levine AS (1982) Corticotropin releasing factor, groming and ingestive behavior. Life Sci 31:1459–1464
Rivier J, Rivier C, Vale W (1984) Synthetic competitive antagonists of corticotropin-releasing factor: effect on ACTH secretion in the rat. Science 224:889–891
Shephard RA, Broadhurst PL (1982) Hyponeophagia and arousal in rats: effect of diazepam, 5-methoxy-N,N-dimethyltryptamine,d-amphetamine and food deprivation. Psychopharmacology 78:368–372
Sherman JE, Kalin NH (1987) The effects of ICV-CRH on novelty-induced behavior. Pharmacol Biochem Behav 26:699–703
Shibasaki T, Kim YS, Yamauchi N, Masuda A, Imaki T, Hotta M, Demura H, Wakabayashi I, Ling N, Shizume K (1988a) Antagonistic Effect of somatastatin on corticotropin-releasing factor-induced anorexia in the rat Life Sci 42:329–334
Shibasaki T, Yamauchi N, Kato Y, Masuda A, Imaki T, Hotta M, Demura H, Oono H, Ling N, Shizume K (1988b) Involvement of Corticotropin-releasing factor in restraint stress-induced anorexia, and reversion of the anorexia by somatostatin in the rat Life Sci 43:1103–1110
Smith SR, Bedsoe T, Chhetri MK (1975) Cortisol metabolism and the pituitary-adrenal axis in adults with protein-calorie malnutrition. J Clin Endocrinol Med 40[1]:43–52
Suemaru S, Hashimoto K, Hattori T, Inoue H, Kageyama J, Ota Z (1986) Starvation-induced changes in rat brain corticotropin-releasing factor (CRF) and pituitary-adrenocortical response. Life Sci 39:1161–1166
Swerdlow NR, Britton KT, Koob GF (1989) Potentiation of acoustic startle by corticotropin-releasing factor (CRF) and by fear are both reversed by alpha-helical CRF (9-41). Neuropsychopharmacology 2[4]:285–292
Takahashi LK, Kalin NH (1989) Role of corticotropin-releasing factor in mediating the expression of defensive behavior. In: Blanchard RJ, Brain PF, Blanchard DC, Parmigiani S (eds) Ethoexperimental approaches to the study of behavior. Kluwer Dordecht, Boston London, pp 580–594
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Heinrichs, S.C., Koob, G.F. Corticotropin-releasing factor modulates dietary preference in nutritionally and physically stressed rats. Psychopharmacology 109, 177–184 (1992). https://doi.org/10.1007/BF02245497
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DOI: https://doi.org/10.1007/BF02245497