Summary
Two possible mechanisms for oxidative phosphorylation are suggested, based on participation of quinones in the process.
Both of them postulate the 1–4 addition of inorganic phosphate on a reactive quinone isomer (the quinone-methide II) without exchange of the quinone oxygen atoms. They also account for the P1-18OH2 exchange observed during oxidative phosphorylation.
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Literature
Ciba Foundation Symposium on Quinones in Electron Transport (Churchill, London 1961).
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Dans deux ouvrages récentsL. L. Ingraham,Biochemical Mechanisms (John Wiley, 1962), p. 47 etE. M. Kosower,Molecular Biochemistry (McGraw Hill, 1962), p. 21, les auteurs envisagent une estérification directe par l'anion phosphate (éventuellement complexé par Mg++) de l'anion d'une hydroquinone ou d'une semi-quinone, donc sans échange de l'oxygène quinonique.
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Communication présentée au Symposium International de Chimie organique des Produits Naturels, Bruxelles (12–15 juin 1962). Résumé dans: Industrie Chimique Belge27, 558 (1962).
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Vilkas, M., Lederer, E. Sur un mécanisme possible de la phosphorylation oxydative. Experientia 18, 546–549 (1962). https://doi.org/10.1007/BF02172167
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DOI: https://doi.org/10.1007/BF02172167