Summary
The GC levels of codon third positions from 49 genomes coveering a wide phylogenetic range are linearly correlated with the GC levels of the corresponding genomes. Three different relationships have been found: one for prokaryotes and viruses, one for lower eukaryotes, and one for vertebrates. All points not fitting the first relationship can be brought into quasi coincidence with it when plotted against GC levels of coding sequences.
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References
Bernardi G, Olofsson B, Filipski J, Zerial M, Salinas J, Cuny G, Meunier-Rotival M, Rodier F (1985) The mosaic genome of warm-blooded vertebrates. Science 228:953–958
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Bernardi, G., Bernardi, G. Codon usage and genome composition. J Mol Evol 22, 363–365 (1985). https://doi.org/10.1007/BF02115693
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DOI: https://doi.org/10.1007/BF02115693