Summary
Sequence divergence between the 3′ long terminal repeats (LTR) of avian reticuloendotheliosis virus (REV), deletion variant proviral clone 2-20-4, and spleen necrosis virus (SNV)—proviral clones 14-44, 60, and 70—was found to involve two classes of base substitutions: low-frequency interspersed and high-frequency clustered substitutions. Clones 2-20-4 and 14-44 have diverged 4.4% owing to low-frequency substitutions. In contrast, two high-frequency substitution segments have diverged by 30% and 29%, respectively. Clustered substitutions appear to be located either within or next to tandem repeats, suggesting their introduction concomitant with sequence deletions and duplications commonly associated with such repeats. A new 19-bp tandem repeat is found in clone 2-20-4. Its sequence could have evolved from the 26-bp repeats found in the SNV clones.
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Notani, G., Sauerbier, W. Sequence instability in the long terminal repeats of avian spleen necrosis virus and reticuloendotheliosis virus. J Mol Evol 25, 241–247 (1987). https://doi.org/10.1007/BF02100017
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DOI: https://doi.org/10.1007/BF02100017