Summary
Fourier analysis, previously introduced by Liquori et al. (1983, 1986), has been applied to the primary structures of two core proteins of human T-lymphotropic leukemia retroviruses HTLV-1 and HTLV-II. The resulting autocorrelation functions display striking patterns that can be interpreted in terms of an approximately fourfold quasi-periodicity of the primary structures.
Self-alignments of the amino acid sequences containing a few gaps are consistent with the above finding and suggest that the tertiary structure of these two homologous core proteins contains alpha-helical and delta-helical segments, the latter being characteristic of the threefold helix present in collagen structure.
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Liquori, A.M., Sadun, C. & Battisti, A. Quasi-periodic primary structructures of core proteins of human T-lymphotropic leukemia retroviruses. J Mol Evol 26, 269–273 (1987). https://doi.org/10.1007/BF02099858
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DOI: https://doi.org/10.1007/BF02099858