Abstract
Captopril enhanced exocytotic enzyme secretion from rabbit peritoneal neutrophils activated by suboptimal concentrations of fMet-Leu-Phe. For optimal enhancement the presence of Ca2+ was required. Captopril did not induce enzyme secretion by its own, and there was little effect on PMA-induced exocytosis. Cyclic GMP level of neutrophils was transiently enhanced by captopril. Methylene blue inhibited both captopril-induced enhancement of enzyme release and of cGMP levels. From our studies and from reports in the literature it appears that cGMP level-enhancing compounds may have both activating or inhibitory properties.
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Elferink, J.G.R. Captopril-induced enhancement of fMet-Leu-Phe-activated enzyme secretion from neutrophils. Agents and Actions 38 (Suppl 2), C136–C138 (1993). https://doi.org/10.1007/BF01991163
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DOI: https://doi.org/10.1007/BF01991163