Abstract
Blood monocytes from patients with RA exhibited a greater binding to monolayers of umbilical cord vein endothelium than monocytes from control subjects (mean 42% increase;p<0.01). When control monocytes were added to TNF or IL-1 treated endothelium their adhesion was enhanced (mean 24% increase;p<0.05), whereas the number of monocytes from RA patients binding to TNF or IL-1 treated monolayers was less than that adhering to untreated endothelial cells (mean 22% inhibition;p<0.02). The surface expression of CD11b/CD18 on RA monocytes was increased and pretreatment of normal and RA cells with an anti-CD18 monoclonal antibody inhibited their attachment to untreated and cytokine-treated endothelial cells. Normal blood monocytes activated with LPS demonstrated an enhanced binding to untreated cultures (mean 23% increase;p<0.05) and an inhibited attachment to cytokine-treated endothelial cells. This study suggests that blood monocytes in RA may be activated and that this property modifies the attachment of these cells to normal and “inflammatory” endothelium.
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Mazure, G., Jayawardene, S.A., Perry, J.D. et al. Abnormal binding properties of blood monocytes in rheumatoid arthritis. Agents and Actions 38 (Suppl 2), C41–C43 (1993). https://doi.org/10.1007/BF01991131
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DOI: https://doi.org/10.1007/BF01991131