Abstract
The development of two models of acute inflammation (carrageenan-induced foot oedema and pleurisy) was studied in rats after 1 month of a 0.2 p.p.m. copper-deficient diet and after 5 months of a 0.6–0.8 p.p.m. copper-deficient diet.
A ‘pro-inflammatory’ effect of copper deficiency was observed with the 0.2 p.p.m. diet, whilst no effect was evident following the 0.6–0.8 p.p.m. copper-deficient diet.
These results are briefly commented upon.
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Milanino, R., Conforti, A., Fracasso, M.E. et al. Concerning the role of endogenous copper in the acute inflammatory process. Agents and Actions 9, 581–588 (1979). https://doi.org/10.1007/BF01968131
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DOI: https://doi.org/10.1007/BF01968131