Abstract
Serotonin was localized to mast cells in the adventitia of the rat portal vein by indirect immunohistochemistry. The mastocytes where preferentially localized to a region delimited by the pyloric and splenic veins. Since neither 48/80 nor reaginic antibody induced a significant change in the intrinsic spontaneous activity of the portal vein it would appear that the mast cells are not involved in a direct vasomotor function. It is suggested that amines released from the mastocytes could regulate blood flow in the vasa vasorum and/or have a role associated with the sensory functions displayed by this vein.
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Barja, F., Mathison, R. & Kursner, C. Immunohistochemical evidence for mast cells containing 5-hydroxytryptamine in the rat portal vein. Agents and Actions 18, 508–511 (1986). https://doi.org/10.1007/BF01964955
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DOI: https://doi.org/10.1007/BF01964955