Abstract
The chronotropic response (Δ rate) to histamine (1.4 to 1.8×10−6 M) of isolated atria from antiestrogen (tamoxifen)-pretreated immature female rabbit was investigated. Tamoxifen treatment (1.0 and 10.0 mg/kg/day for 14 days) had no significant effect on the Δ rate. The Rmax and D1/2max were not significantly different in the two tamoxifen-treated groups compared to the oil-treated (1.0 ml/kg/day for 14 days) control group. Cimetidine (2.8×10−7 M) inhibited the Δ rate to histamine in all groups: control, 27%; tamoxifen (1.0 mg/kg), 38%; and tamoxifen (10.0 mg/kg), 28%. Only the low dose of tamoxifen was found to be estrogenic (uterotropic). We conclude that tamoxifen pretreatment, both at estrogen-agonist and estrogen-antagonist doses, is without effect on atrial chronotropic response to histamine.
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Baksi, S.N., Hughes, M.J. Effect ofin vivo antiestrogen pretreatment on rabbit atrial chronotropic response to histamine. Agents and Actions 18, 463–467 (1986). https://doi.org/10.1007/BF01964947
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DOI: https://doi.org/10.1007/BF01964947