Summary
The interactions of Ni(II) cation with a representative suite of purine bases and the respective nucleosides and nucleotides have been studied by ultraviolet difference spectroscopy. Apparent association constants, Kapp, were determined for each system at pH 7.0, using computer linear regression coupled with an iteration technique. The specificity of binding of Ni2+ for the purine nucleotides studied at pH 7.0 was 5′-GMP > 5′-IMP > 5′-AMP; a similiar ordering was also found for the respective nucleosides and bases. In this study binding was not observed for the suite of pyramidines used, although a Ni2+ - cytidine complex has been observed (Fiskin and Beer, 1965). It was also found that Ni2+ bound more strongly to the purine 5′-nucleotides than to the respective nucleosides and bases. These trends are explained in terms of metal-ligand bonds and available bonding positions on the ligands. A role for metal-ion-nucleotide types of complexes is suggested in the processes that might have given rise to the origin of life.
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References
Banin A, Naurot J (1975) Science 189:550
Beck MT (1980) Prebiotic coordination chemistry. In: Sigel H (ed) Ions in Biol Sys 7, Marcel Dekker, New York, 1–28
Coward NA, Kiser RW (1966) J Phys Chem 70:213–217
Donovan JW (1969) In: Leach SJ (ed) Physical principles and techniques of protein chemistry, Part A, Academic Press, New York, pp 102–170
Egami F (1974) J Mol Evol 4:113–120
Eichhorn GL (ed) (1973) Inorganic biochemistry, Vol I, pp 3–101, Vol II, pp 1191–1245, Elsevier Scientific Publishing Co, New York
Erickson JO, Bramston-Cook R (1973) Varian Intru Applic 7:(4),10–12
Fiskin AM, Beer M (1965) Biochem 4:1289–1294
Flaschka H, Schwarzenbach G (1969) In: Complexometric titrations, London, Methuen and Co, pp 248–249
Frey CM, Stueher JE (1972) J Am Chem Soc 94:8898–8904
Frey C, Stueher J (1974) In: Sigel H (ed) Metal ions in biological systems, l: Marcel Dekker, New York, p 86–122
Gellert RW, Bau R (1979) In: Sigel H (ed) Met Ions in Biol 8, Marcel Dekker, New York, p 1–55
Harbers E, Damagk G, Müller W (1968) In: Introduction to nucleic acids, New York, Reinhold, p 28
Heller MJ, Jones AJ, Tu AT (1970) Biochem 9:4981–4986
Herskovits TT, Laskowski M Jr (1973) J Biol Chem 237:2481–2492
Izatt RM, Christensen JJ, Rytting JH (1971) Chem Rev 71:439–481
Lawless JG, Edelson EH (1980) The possible role of metal ions and clays in prebiotic chemistry. In: Holmquist R (ed) COSPAR, Life Sciences and Space Research, Vol VII, Pergamon Press, New York, pp 83–87
Mariam YH, Martin RB (1979) Inorg Chim Acta 35:23–28
Martin RB, Mariam YH (1979) In: Sigel H (ed) Met Ions Biol Syst 8, Marcel Dekker, New York, pp 57–124
Marzilli LG (1977) In: Lippard (ed) Progress in inorganic chemistry, Vol 23. New York, John Wiley and Sons, pp 255–377
McClendon JH (1976) J Mol Evol 8:175–195
Orenberg JB, Fisher BE, Sigel H (1980) J Inorg Nucl Chem 42:785–792
Orgel LE (1974) Sedimentary minerals under reducing conditions. In: Dose K, Fox SW, Deborin GA, Paulouskaya TE (eds) The origin of life and evolutionary biochemistry, Plenum Press, New York
Phillips R (1966) Chem Rev 66:501–527
PL Biochemicals, Inc (1956) Ultraviolet absorption spectra of 5′-ribonucleotides. Circ No ORIO, Milwaukee, Wisconsin
Reinert H, Weiss R (1969) Z Physiol Chem 350:1310–1320
Scheller KH, Abel THJ, Polanyi PE, Wenk PK, Fischer BE, Sigel H (1980) Eur J Biochem 107:455–466
Schneider PW, Britzinger H, Erlenmeyer H (1964) Helv Chim Acta 47:992–1002
Sigel H (1973) In: Sigel H (ed) Met Ions Biol Syst 2:63–125, Marcel Dekker, New York
Sigel H (1975) J Am Chem Soc 97:3209–3214
Sillen LG, Martell AE (1964) In: Stability constants of metal-ion complexes, Spec Publ No 17, Chem Soc, London
Smith RM, Martell AE (1976) In: Critical stability constants, Vol 4. Inorganic complexes. Plenum Press, New York and London
Taylor RS, Diebler H (1976) Bioinorg Chem 6:247–264
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Orenberg, J.B., Kjos, K.M., Winkler, R. et al. Binding of nickel (II) to 5′-nucleoside monophosphates and related compounds. J Mol Evol 18, 137–143 (1982). https://doi.org/10.1007/BF01810833
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DOI: https://doi.org/10.1007/BF01810833