Summary
The problem of determining the minimum number of nucleotide substitutions required to account for the descent of a set of amino acid sequences given their ancestral relationships (phylogeny) has been studied. A method expanding upon the earlier work of Fitch (1971) for a set of nucleotide sequences is presented and its merits compared to the method of Mooreet al. (1973).
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Fitch, W.M., Farris, J.S. Evolutionary trees with minimum nucleotide replacements from amino acid sequences. J Mol Evol 3, 263–278 (1974). https://doi.org/10.1007/BF01796042
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DOI: https://doi.org/10.1007/BF01796042