Summary
Pituitary growth hormone and prolactin, together with the homologous placental hormones, comprise a family of related protein hormones. Complete or partial amino acid sequences of seven mammalian growth hormones, six mammalian prolactins and one placental lactogen are available, and have been compared. A phylogenetic tree has been constructed which describes the relationships within the family. At least two gene duplications have occurred during the evolution of these proteins. Rates of evolution in the family have been quite variable, the overall rate of evolution having been apparently fairly slow, but having increased markedly on several occasions, most notably in the evolution of human (and, on the basis of immunological relationships, probably other primate) growth hormones and rat (and possibly other rodent) prolactins.
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Bellair JT (1972) Biochem Biophys Res Commun 46:1128–1134
Bewley TA, Dixon JS, Li CH (1972) Int J Pept Protein Res 4:281–287
Cadman H, Wallis M (1980) J Endocrinol 87:53P–54P
Davies RV (1974) Studies on sheep and rat growth hormones. D Phil thesis, University of Sussex
Dayhoff MO (1972) Atlas of protein sequence and structure, vol. 5. National Biomedical Research Foundation, Washington DC
Dayhoff MO (1978) Atlas of protein sequence and structure. vol 5, supplement 3. National Biomedical Research Foundation, Washington DC
Farmer SW, Papkoff H, Hayashida T (1974) Endocrinology 95:1560–1565
Farmer SW, Papkoff H, Hayashida T (1976) Endocrinology 99:696–700
Fellows RE (1973) Recent Prog Horm Res 29:404–408
Fellows RE, Bolander FF, Hurley TW, Handwerger S (1976) In: Pecile A, Müller EE (eds), Growth hormone and related peptides. Excerpta Medica, Amsterdam, p 315
Ferńandez HN, Peña C, Poskus F, Biscoglio MJ, Paladini AC, Dellacha JM, Santomé JA (1972) FEBS Lett 25:265–270
Fiddes JC, Seeburg PH, DeNoto FM, Hallewell RA, Baxter JD, Goodman HM (1979) Proc Natl Acad Sci USA 76:4294–4298
Goeddel DV, Heyneker HL, Hozumi T, Arentzen R, Itakura K, Yansura DG, Ross MJ, Miozzari G, Crea R, Seeburg PH (1979) Nature 281:544–548
Gráf L, Li CH (1974) Biochem Biophys Res Commun 56:168–176
Gubbins EJ, Maurer RA, Hartley JL, Donelson JE (1979) Nucleic Acids Res 6:915–930
IUPA-IUB Commission on biochemical Nomenclature (1968) J Biol Chem 243:3557–3559
Kawauchi H, Tubokawa M (1979) Int J Pept Protein Res 13:229–234
King JL, Jukes TH (1969) Science 164:788–798
Lewis UJ, Singh RNP, Lindsey TT, Seavey BK, Lambert TH (1973) In: Raiti S (ed), Advances in human growth hormone research. U.S. Department Health, Education and Welfare, Washington DC, p 349
Li CH (1976) Int J Pept Protein Res 8:205–224
Li CH, Dixon JS, Gordon D, Knorr J (1972) Int J Pept Protein Res 4:151–153
Li CH, Dixon JS, Lo TB, Schmidt KD, Pankov YA (1970) Arch Biochem Biophys 141:705–737
Martial JA, Hallewell RA, Baxter JD, Goodman HM (1979) Science 205:602–607
Mills JB, Wilhelmi AE (1972) In: Pecile A, Müller EE (eds), Growth and growth hormone. Excerpta Medica, Amsterdam, p 38
Moore GW, Goodman M, Callahan C, Holmquist R, Moise H (1976) J Mol Biol 105:15–37
Niall HD (1972) In: Boyns AR, Griffiths K (eds) Prolactin and carcinogenesis. Alpha Omega Alpha Publishing, Cardiff, p 13
Pankov YA, Bulatov AA, Osipova TA, Keda YA, Sinitsina AL (1977) Biochemistry (USSR) 41:1664–1670 (Translation of Biokhimiya 41:2047–2055)
Papkoff H, Farmer SW, Hayashida T (1979) Ricerca Scientifica ed Educazione Permanente. Supplement 11, Abstract 5. (Abstracts, International Symposium on Growth Hormone and other Biologically Active Peptides)
Parlow AF, Shome B (1976) Fed Proc 35:219
Robertson MC, Friesen HG (1975) Endocrinology 97:621–629
Romer AS (1966) Vertebrate paleontology. 3rd edn. University of Chicago Press, Chicago
Santomé JA, Dellacha JM, Paladini AC, Peña C, Biscoglio MJ, Daurat ST, Poskus E, Wolfenstein CEM (1973) Eur J Biochem 37:164–170
Seeburg PH, Shine J, Martial JA, Baxter JD, Goodman HM (1977) Nature 270:486–494
Sherwood LM, Handwerger S, McLaurin WD, Lanner M (1971) Nature (London) New Biol 233:59–61
Shine J, Seeburg PH, Martial JA, Baxter JD, Goodman HM (1977) Nature 270:494–499
Shome B, Parlow AF (1977) J Clin Endocrinol Metab 45:1112–1115
Tashjian AH, Levine L, Wilhelmi AE (1965) Endocrinology 77:563–573
Wallis M (1971) Biochem J 125:54P–56P
Wallis M (1973) FEBS Lett 35:11–14
Wallis M (1974) FEBS Lett 44:205–208
Wallis M (1975) Biol Rev 50:35–98
Wallis M (1978a) Proc Aust Biochem Soc 11:Q12-Q13
Wallis M (1978b) In: Weinstein B (ed), Chemistry and biochemistry of amino acids, peptides and proteins, vol 5. Dekker, New York, p 213
Wallis M, Davies RV (1974) Biochem Soc Trans 2:911–912
Wallis M, Davies RV (1976) In: Pecile A, Müller EE (eds), Growth hormone and related peptides. Excerpta Medica, Amsterdam, p 1
Young JZ (1962) The life of vertebrates, 2nd edn. Oxford, Oxford University Press
Yudaev NA, Pankov YA, Elizarova GP, Han Z, Nikolaeva OP (1975) Bioorganicheskaya Khimiya 1:97–112
Zakin MM, Poskus E, Langton AA, Ferrara P, Santomé JA, Dellacha JM, Paladini AC (1976) Int J Pept Protein Res 8:435–444
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Wallis, M. The molecular evolution of pituitary growth hormone prolactin and placental lactogen: A protein family showing variable rates of evolution. J Mol Evol 17, 10–18 (1981). https://doi.org/10.1007/BF01792419
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DOI: https://doi.org/10.1007/BF01792419