Summary
A method is described for assessing the non-randomness of protein compositions, based on the chi-squared statistic for the differences between the observed numbers of residues of each type and the numbers expected for a random distribution of codons. The analysis indicates that changes in at least 30% of the residues in natural proteins are selected against.
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Cornish-Bowden, A., Marson, A. Evaluation of the non-randomness of protein compositions. J Mol Evol 10, 231–240 (1977). https://doi.org/10.1007/BF01764598
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DOI: https://doi.org/10.1007/BF01764598