Summary
The nucleotide sequence of a segment of U1 and U3b small RNAs (sRNAs) is shown to have a high complementarity with the nucleotide sequence of a part of the leader region of almost all eukaryotic genes studied so far. The complementary region of U3b is located in the unpaired segment of the secondary structure of U3b constructed by Reddy et al. (1979). A similar complementarity is also observed between these RNAs and the leader regions of eukaryotic viruses, but the complementary region is not always identical with that for eukaryotic genes. Complementarity is also observed between the 3′ end of 18S rRNA and a segment of U1 or U3b which is almost contiguous to the region complementary with mRNA. These observations suggest that U1 and U3b may be involved in mRNA processing and transport in the nucleus or in translation in the cytoplasm. In addition to U1 and U3b, another sRNA, i.e., 4.5S RNAI, is shown to have segments which are homologous to the Hogness box of the flanking region of gene and the Proudfoot-Brownlee (PB) box of mRNA near the poly(A) attachment site. The two segments which are complementary with these boxes are located almost contiguously on a co-joined loop of the secondary structure of 4.5S RNAI constructed by Ro-Choi et al. (1972). Since the Hogness box and PB box are both considered as a recognition site by the RNA polymerase, it is possible that 4.5S RNAI is involved in mediating gene transcription.
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References
Baralle FE, Brownlee GG (1978) Nature 274:84–87
Bell GI, Pictet RL, Rutter WJ, Cordell B, Tischer E, Goodman HM (1980) Nature 284:26–32
Bernard O, Hozumi N, Tonegawa S (1978) Cell 15:1133–1144
Branlant C, Krol A, Ebel JP, Lazar E, Gallinaro H, Jacob M, Sri-Widata J, Jeanteur P (1980) Nucleic Acids Res 8:4143–4154
Busch H, personal communication
Chang JC, Temple GF, Poon R, Neumann KH, Kan YN (1977) Proc Natl Acad Sci USA 74:5145–5149
Cochet M, Gannon F, Hen R, Maroteaux L, Perrin F, Chambon P (1979) Nature 282:567–574
Cordell B, Bell G, Tischer E, DeNoto FM, Ullrich A, Pictet R, Rutter WJ, Goodman HM (1979) Cell 18:533–543
Derynck R, Content J, DeClercq E, Volckaert G, Tavernier J, Devos R, Fiers W (1980) Nature 285:542–547
Flytzanis C, Alonso A, Louis C, Krieg L, Sekeris CE (1978) FEBS Lett 96:201–206
Gallwitz D, Sures I (1980) Proc. Natl. Acad Sci USA 77:2546–2550
Gannon F, O'Hare K Perrin F, LePennec JP, Benoist C, Cochet M, Breathnach R, Royal A, Garapin A, Cami B, Chambon P (1979) Nature 278:428–434
Grosschedl R Birnstiel ML (1980) Proc Natl Acad Sci USA 77:1432–1436
Hagenbüchle O, Bovey R, Young RA (1980) Cell 21:179–187
Hagenbüchle O, Santer M, Steitz JA (1978) Cell 13:551–563
Heindell HC, Liu A, Paddock GV, Studnick GM, Salser WA (1978) Cell 15:43–54
Hellung-Larsen P, Fredericksen S (1977) Comp Biochem Physiol 58B:273–281
Jelinek W, Leinwand L (1978) Cell 15:205–214
Kanehisa T, Fujitani H, Sano M, Tanaka T (1971) Biochim Biophys Acta 240:46–55
Kano Y, Komatsu H, Nakanoin K, Fujiwara Y (1978) Exp Cell Res 115:444–448
Konkel DA, Maizel Jr, JV, Leder P, (1979) Cell 18:865–873
Lerner MR, Boyle JA, Mount SM, Wolin SL, Steitz JA (1980) Nature 283:220–224
Lerner MR, Steitz JA (1979) Proc Natl Acad Sci USA 76:5495–5499
Lomedico P, Rosenthal N, Efstratiadis A, Gilbert W, Kolodner R, Tizard R (1979) Cell 18:545–558
Nishioka Y, Leder P (1979) Cell 18:875–882
Pasek M, Goto T, Gilbert W, Zink B, Schaller H, Mackay P, Leadbetter G, Murray K (1979) Nature 282:575–579
Proudfoot NJ, Brownlee GG (1976) Nature 263:211–214
Reddy R, Henning D, Busch H (1979) J Biol Chem 254:11097–11105
Reddy R, Ro-Choi TS, Henning D, Busch H (1974) J Biol Chem 249:6486–6494
Richards RI, Shine J, Ullrich A, Wells JRE, Goodman HM (1979) Nucleic Acids Res 7:1137–1146
Ro-Choi TS, Henning D (1977) J Biol Chem 252:3814–3820
Ro-Choi TS, Reddy R, Henning D, Takano T, Taylor CW, Busch H (1972) J Biol Chem 247:3205–3222
Rogers J, Wall R (1980) Proc Natl Acad Sci 77:1877–1879
Roskam WG, Rougeon F (1979) Nucleic Acids Res 7:305–320
Salser W (1977) Cold Spring Harb Symp 985–1002
Seeburg PH, Shine J, Martial JA, Baxter JD, Goodman HM (1977) Nature 270:486–494
Seidman JG, Leder A, Edgell MH, Polsky F, Tilghman SM, Tiemeier DC, Leder P (1978) Proc Natl Acad Sci USA 75:3881–3885
Siedman JG, Max EE, Leder P (1979) Nature 280:370–375
Shibata H, Ro-Choi TS, Reddy R, Choi YC, Henning D, Busch H (1975) J Biol Chem 250:3909–3920
Sures I, Levy S, Kedes LH (1980) Proc Natl Acad Sci USA 77:1265–1269
Taniguchi T, Mantei N, Schwarzstein M, Nagata S, Muramatsu M, Weissman C (1980) Nature 285:547–549
Ting AC Tsai MJ, O'Malley BW (1980) In press
Tonegawa S, Maxam AM, Tizard R, Bernard O, Gilbert W (1978) Proc Natl Acad Sci USA 75:1485–1489
Tsujimoto Y, Suzuki Y (1979) Cell 18:591–600
Van Ooyen A, van den Berg J, Mantei N, Weissman C (1979) Science 206:337–344
Weinberg RA, Penman S (1968) J Mol Biol 38:289–304
Zieve G, Penman S (1976) Cell 8:19–31
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Gojobori, T., Nei, M. Inter-RNA homology and possible roles of small RNAs. J Mol Evol 17, 245–250 (1981). https://doi.org/10.1007/BF01732762
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DOI: https://doi.org/10.1007/BF01732762