Summary
We have prepared a variety of derivatives of adenosine which, at neutral pH's, carry protonated amine functions. These derivatives form stable helical structures with polyuridylic acid, but the melting points are not substantially higher than those of helical complexes formed by adenosine derivatives lacking cationic groups.
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Abbreviations
- Poly (U):
-
Polyuridylic acid
- A:
-
Adenosine
- pA:
-
Adenosine 5′-phosphate
- H2NpA:
-
Adenosine 5′-phosphoramidate
- SdpA:
-
Spermidine-N-(5′-phosphoadenosine)
- SpA:
-
Spermine-N-(5′-phosphoadenosine)
- EnpA:
-
1,2-Diaminoethane-N-(5′-phosphoadenosine)
- PrnpA:
-
1,3-Diaminopropane-N-(5′-phosphoadenosine)
- BnpA:
-
1,4-Diaminobutane-N-(5′-phosphoadenosine)
- PnpA:
-
1,5-Diaminopentane-N-(5′-phosphoadenosine)
- HnpA:
-
1,6-Diaminohexane-N-(5′-phosphoadenosine)
References
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Shim, J.L., Lohrmann, R. & Orgel, L.E. Triple helices formed by polyuridylic acid with some adenosine derivatives. J Mol Evol 5, 117–123 (1975). https://doi.org/10.1007/BF01732516
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DOI: https://doi.org/10.1007/BF01732516